Antibiotic therapy in children – Knowledge and behavior of parents

Conclusions: Parents either do not know or insufficiently understand the purpose of the use of antibiotics in the treatment of children's URTI. Parents trust in a doctor's decision concerning antibiotic therapy, but frequently consult the Internet. Doctors give in to parents’ demands and prescribe antibiotics. Not respecting recommendations and antibiotics “self-treatment” are reprehensible. There is a need of educating parents and doctors in the reasonable use of antibiotics.
Source: Pediatria Polska - Category: Pediatrics Source Type: research

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Authors: Shimoni Z, Cohen R, Froom P Abstract Introduction: It is unclear how to prevent the negative impact of inappropriate urine cultures in older acute care patients who have a high rate of asymptomatic bacteriuria.Areas covered: A nonsystematic literature review of the definition, impact, and management of elderly acute care patients with asymptomatic bacteriuria (ASB).Expert opinion: In the elderly, patients with ASB include those with extra-urinary tract diseases (e.g. pneumonia) and those with symptoms/signs that resolve without antibiotic therapy, but the diagnosis of ASB is unclear in febrile patients res...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
We describe a case of vertebral osteomyelitis with associated infection of an abdominal aortic endograft, caused by Coxiella burnetii. Most probably an initial pyogenic vertebral osteomyelitis extended locally to the endograft. Treatment consisted of antibiotic therapy and surgical resection of the infected aortic endograft and in situ reconstruction with autogenous superficial femoral vein grafts.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
Treatment of resistant Pseudomonas aeruginosa infection continues to be a challenge in Latin American countries (LATAM). We synthesize the literature on the use of appropriate initial antibiotic therapy (AIAT) an...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
ConclusionUTI is a significant but common problem in elderly population. Physicians who care for frail elderly patients must be aware of the challenges in the management of asymptomatic UTI, and identifying symptomatic UTI in this population, and their appropriate management strategies. There is strong need in studies to evaluate nonantimicrobial therapies in the prevention of UTI for the frail elderly population.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 25 March 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Po-Yu Liu, Kung-Ching Wang, Yu-Ping Hong, Bo-Han Chen, Zhi-Yuan Shi, Chien-Shun Chiou
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
This study lends additional support to relebactam's use as a β‐lactamase inhibitor in antimicrobial therapy.
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
Abstract The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750-1,000 ml of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycopr...
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research
Conclusions: Empirical antimicrobial therapy should include adequate coverage for Gram-negative pathogens. The antimicrobial regimen should be modified according to the results of the culture and sensitivity testing.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
Rapid diagnostic testing (RDT) can facilitate earlier optimization of the treatment of bloodstream infections, particularly in conjunction with an effective antimicrobial stewardship program (ASP). However, the effective implementation and workflow of RDTs are still a matter of debate, particularly in a pediatric setting. In this issue of the Journal of Clinical Microbiology, L. J. Juttukonda, S. Katz, J. Gillon, J. Schmitz, and R. Banerjee (J Clin Microbiol 58:e01400-19, 2020, investigate the impact of a multiplex, molecular RDT on changes to antimicrobial therapy in an academic child...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Commentary Source Type: research
Tuberculosis (TB) remains as one of the world's deadliest infectious diseases despite the use of standardized antibiotic therapies. Recommended therapy for drug-susceptible TB is up to 6 months of antibiotics. Factors that contribute to lengthy regimens include antibiotic underexposure in lesions due to poor pharmacokinetics (PK) and complex granuloma compositions, but it is difficult to quantify how individual antibiotics are affected by these factors and to what extent these impact treatments. We use our next-generation multi-scale computational model to simulate granuloma formation and function together with antibiotic ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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