S31 Structurally informed analyses of functional connectivity in stroke

Stroke is the leading cause of disability in industrialized countries, has a big impact on quality of life, and is of high socioeconomic relevance. Despite great advances of acute therapy – like thrombolysis and mechanical thrombectomy – approximately 50% of stroke survivors suffer from permanent neurological deficits, mostly because of structural and functional neural network failure.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research

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Publication date: Available online 12 December 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Christopher J. TaylorAbstractIntracerebral haemorrhage (ICH) accounts for around 10–20% of all strokes and results from a variety of disorders. ICH is more likely to result in death or major disability than ischaemic stroke or subarachnoid haemorrhage. Rapid imaging allows early diagnosis and characterization of the localization and severity of the haemorrhage. Patients with significant acute ICH should be managed in a critical care unit. Treatment entails general supportive care, control of blood pressure an...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
In the United States, the economic burden of stroke is more than $72 billion annually.1 Stroke is a leading cause of disability worldwide,2 and approximately 40% of stroke survivors have some degree of lingering functional impairment.3 Stroke survivors often experience stroke impact symptoms in such domains as motor function, cognition, communication, mood, activities of daily living, and social participation4,5 which limit their ability to return home or to work and improve their quality of life.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
Abstract Aim: To translate and cross-culturally adapt the Motor Activity Log (MAL) into Hausa Language.Method: Forward and backward translations of the questionnaire were done by independent language experts who are fluent in Hausa and English language respectively. The experts reviewed the translation process according to Beaton's guidelines. The psychometric properties of the final version were assessed using 68 stroke survivors.Results: There was large (r = 0.932 for AOU, and 0.921 for QOU) and significant (p 
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Abstract Worldwide, millions of individuals suffer an ischemic stroke each year, causing major disability, especially in the elderly, where stroke is the number one cause of disability. However, to date, no effective therapy exists that targets the functional recovery after stroke. After necrosis, neuroinflammation is a common feature of the acute stroke and a major obstacle to tissue restoration. In the lesioned area, the dying neurons release chemotactic signals, such as fractalkine/CX3CL1, which evoke "eat-me" signals that are recognized by microglia expressing complement C3a receptor (C3aR), resultin...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Stroke is the leading cause of disability in adult life. Oropharyngeal dysphagia occurs in 65-90% of patients, and its identification in the acute phase of stroke can prevent complications. The aim of this study was to verify whether oropharyngeal dysphagia during stroke hospitalization is associated with functional capacity, as assessed by the modified Rankin Scale (mRs), and mortality 90 days after stroke.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
"Energy-sensing pathways in ischemia: The counterbalance between AMPK and mTORC". Curr Pharm Des. 2019 Dec 10;: Authors: Cespedes A, Villa M, Benito-Cuesta I, Perez-Alvarez MJ, Ordoñez L, Wandosell F Abstract Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage corresponds in itself to the sum of the lack of nutrients and oxygen contributed by the blood flow. The present review aims to analyze to what extent the lack of each...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Conclusions: The waist-to-height ratio was more closely related to the prevalence of stroke than body mass index, waist circumference, and weight-to-hip ratio among the study participants aged ≥ 40 years.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Complete and rapid revascularization can dramatically reduce disability after large-vessel occlusion (LVO) acute ischemic stroke (AIS). With modern mechanical thrombectomy (MT), we now have a safe and effective method to recanalize occluded cerebral vessels, and in this issue of JAMA Neurology, Kaesmacher et al move the field 1 step closer to achieving the goal of complete revascularization. Cohort studies have demonstrated that even among patients who achieve substantial reperfusion, defined as a Thrombolysis in Cerebral Infarction grade of 2b or greater, those who achieve the highest grades of reperfusion have quantifiab...
Source: JAMA Neurology - Category: Neurology Source Type: research
Conclusions: Studies showed heterogeneity in selecting outcomes and timings for assessment. There is evidence for assessing the evidence of orthosis-based gait rehabilitation after stroke through activity outcome measures, primarily the gait speed, recorded by non-wearable motion capture systems. A unified methodology considering wearable sensors for tracking baseline and follow-up measures is needed.Implications for rehabilitationThere is evidence on use activity outcome measures to assess the meaningful evidence-based practice of orthosis-based gait rehabilitation in post-stroke.Gait speed was the primary outcome measure...
Source: Disability and Rehabilitation. Assistive Technology. - Category: Rehabilitation Authors: Tags: Disabil Rehabil Assist Technol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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