Progress and problems in vaccination against necrotic enteritis in broiler chickens.

Progress and problems in vaccination against necrotic enteritis in broiler chickens. Avian Pathol. 2014 Jul 1;:1-33 Authors: Mot D, Timbermont L, Haesebrouck F, Ducatelle R, Van Immerseel F Abstract Necrotic enteritis in broilers is caused by Clostridium perfringens type A strains that produce the NetB toxin. It is one of the gastrointestinal diseases in poultry that has gained worldwide importance during the last decade due to efforts to improve broiler performance. Prevention strategies include avoiding predisposing factors, such as coccidiosis, and in-feed supplementation with a variety of feed additives. However, vaccination with modified toxin or other secreted immunogenic proteins seems a logical preventive tool for protection against a toxin-producing bacterium. Formalin-inactivated crude supernatant has been used initially for vaccination. Several studies have been carried out recently to identify the most important immunogenic and protective proteins that can be used for vaccination. These include the NetB toxin, as well as a number of other proteins. There is evidence that immunization with single proteins is not protective against severe challenge and that combinations of different antigens are needed. Most published studies have used multiple dosage vaccination regimens that are not relevant for practical use in the broiler industry. Single vaccination regimens for day-old chicks appear to be non-protective. This review d...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research