Epilepsy in fragile ‐X‐syndrome mimicking panayiotopoulos syndrome: Description of three patients

We describe the clinical features, EEG findings and evolution in three patients affected by Fragile‐X‐syndrome and epilepsy mimicking Panayiotopoulos syndrome. Age at seizure onset was between 4 and about 7 years. Seizures pattern comprised a constellation of autonomic symptoms with unilateral deviation of the eyes and ictal syncope. Duration of the seizures could be brief or lengthy. Interictal EEGs revealed functional multifocal abnormalities. The evolution was benign in all patients with seizures remission before the age of 14. This observation expands the spectrum of benign epileptic phenotypes present in Fragile‐X‐syndrome and may be quite helpful in guiding anticonvulsant management and counseling families as to expectations regarding seizure remission.

Source: American Journal of Medical Genetics Part A - August 16, 2017 Category: Genetics & Stem Cells Authors: Paolo Bonanni, Susanna Casellato, Franco Fabbro, Susanna Negrin Tags: CLINICAL REPORT Source Type: research