Proposed: Trial of Vitamin Derivative to Prevent Melanoma Proposed: Trial of Vitamin Derivative to Prevent Melanoma

The vitamin B3 derivative nicotinamide was previously shown to reduce nonmelanoma skin cancers in a phase 3 trial.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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ConclusionTo date, there is paucity of data from developing countries. We reported the results from a National Health Institute in Mexico including a large cohort with a long follow-up, demonstrating differences within frequencies and risks compared to other regions of the world.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
We read with interest the article by Egeler et al,1 and would like to highlight that inpatient burden for managing head and neck skin cancer is not restricted to high income countries (HIC), but also prevalent in low and middle income countries (LMIC). Cutaneous malignancies are one of the ten most prevalent cancers in sub-Saharan Africa,2 and curative treatment is challenging due to delays in diagnosis in Fitzpatrick type VI skin, late presentation, prevalence of albinism and human immunodeficiency virus (HIV), and limitations in access to healthcare.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
Abstract It is technically impossible to ascertain cumulative UVR exposure with the Korean National Health Insurance claims database due to the lack of information on each treatment dose. As an alternative, we stratified our patients based on the number of phototherapy sessions (no phototherapy,
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
ABSTRACTUV ‐chromophores contained in human skin may act as endogenous sensitizers of photooxidative stress and can be employed therapeutically for the photodynamic elimination of malignant cells. Here we report that 6‐formylindolo[3,2‐b]carbazole (FICZ), a tryptophan‐derived photoproduct and endoge nous aryl hydrocarbon receptor agonist, displays activity as a nanomolar sensitizer of photooxidative stress, causing the photodynamic elimination of human melanoma and nonmelanoma skin cancer cellsin vitro andin vivo. FICZ is an efficient UVA/Visible photosensitizer having absorbance maximum at...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
ConclusionsDemographics and factors including fall/fracture history, comorbidities, and medications contribute to imminent risk of fracture in elderly patients.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
Purpose of review To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence. Recent findings The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Pediatric melanoma often pres...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: DERMATOLOGY: Edited by Albert C. Yan Source Type: research
In this study, our aim was to assess the occurrence of cutaneous malignancies in 97 HIV-positive individuals visited in our Institute, and to evaluate the association with immunological parameters, as well as combination antiretroviral therapy (cART) duration.
Source: AIDS - Category: Infectious Diseases Tags: Research Letters Source Type: research
CONCLUSION Mohs micrographic surgery is at least equivalent to WME for the treatment of melanoma of the external ear.
Source: Dermatologic Surgery - Category: Dermatology Tags: Original Article Source Type: research
Abstract Cratoxylum formosum Dyer is a medicinal plant widely found in Asia and commonly consumed for food and folk medicine. It is rich in phenolic compounds. The present study utilized water crude extract of C. formosum leaves to synthesize zinc oxide nanoparticles (ZnO NPs) by green synthesis. The synthesized ZnO NPs with the average electronic band gap ∼3  eV were obtained and found to either have spherical shape or sheet-like structures depending on synthesis process and concentration of crude extract. Higher concentration of C. formosum extract also eliminates impurity of Zn(OH)2 during the synthesis. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Abstract BACKGROUND: A raised platelet count (thrombocytosis) measuring>400 × 109/l is associated with high cancer incidence. It is uncertain whether platelet counts at the upper end of the normal range (high-normal: 326-400 × 109/l) are also associated with cancer. AIM: To investigate cancer incidence following a normal platelet count in primary care. DESIGN AND SETTING: A prospective cohort study was undertaken using data from the Clinical Practice Research Datalink and National Cancer Registration and Analysis Service, dating from 1 May 2005 to 30 April 2014. METHOD: One-year cance...
Source: The British Journal of General Practice - Category: Primary Care Authors: Tags: Br J Gen Pract Source Type: research
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