Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin –piperaquine in healthy volunteers
ConclusionsPharmacokinetic–pharmacodynamic modelling and simulation in healthy adult volunteers suggested that therapeutic doses of DHA–piperaquine in the prevention or treatment of P. falciparum malaria are unlikely to be associated with dangerous QT prolongation.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Palang Chotsiri, Thanaporn Wattanakul, Richard M. Hoglund, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Daniel Blessborn, Podjanee Jittamala, Nicholas J. White, Nicholas P.J. Day, Joel Tarning Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research