Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism

In conclusion, circulating miR-200c are up-regulated in FH, probably due to oxidative stress and inflammation and via a miR-33a/b-ZEB1-dependent mechanism. This study could be the first evidence to point to the use of miR-33a/b and miR-200c, as early biomarkers of CVD in paediatric FH.

Source: Clinical Science - August 15, 2017 Category: Biomedical Science Authors: D'Agostino, M., Martino, F., Sileno, S., Barilla, F., Beji, S., Marchetti, L., Gangi, F. M., Persico, L., Picozza, M., Montali, A., Martino, E., Zanoni, C., Avitabile, D., Parrotto, S., Capogrossi, M. C., Magenta, A. Tags: PublishAheadOfPrint Source Type: research