Altered corticostriatal pathway in first-episode paranoid schizophrenia: resting-state functional and causal connectivity analyses

Until today, the etiology of schizophrenia remains unclear. A dysconnectivity hypothesis has been proposed that schizophrenia is associated with certain changes in neuronal connectivity during the neural developmental process(Pettersson-Yeo et al., 2011; Stephan et al., 2009). Converging evidence suggests that schizophrenia is related to disruptive connectivity and functional integration failures in large-scale brain networks (Pettersson-Yeo et al., 2011; Woodward et al., 2012; Wotruba et al., 2014; Yu et al., 2012; Zhou et al., 2015).

Source: Psychiatry Research: Neuroimaging - August 15, 2017 Category: Psychiatry Authors: Huan Huang, Chang Shu, Jun Chen, Jilin Zou, Cheng Chen, Shihao Wu, Ling Xiao, Zhongchun Liu, Huiling Wang, Yuan Zhou, Gaohua Wang, Tianzi Jiang Source Type: research