Defining the Phenotype of Antibody-Mediated Rejection in Kidney Transplantation: Advances in Diagnosis of Antibody Injury

The diagnostic criteria for antibody-mediated rejection (ABMR) are constantly evolving in light of the evidence. Inclusion of C4d-negative ABMR has been one of the major advances in the Banff Classification in recent years. Currently Banff 2015 classification requires evidence of donor specific antibodies (DSA), interaction between DSA and the endothelium, and acute tissue injury (in the form of microvasculature injury (MVI); acute thrombotic microangiopathy; or acute tubular injury in the absence of other apparent cause).
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Tags: Review article Source Type: research