MRI evidence of acute inflammation in leukocortical lesions of patients with early multiple sclerosis
Conclusions: The presence of enhancing lesions affecting the cortex and adjacent white matter, although transient and not frequent, suggests that at least some cortical lesions are related to blood–brain barrier disruption. Our data support the concept that there may be an acute inflammatory phase in the development of leukocortical MS lesions. Clinicaltrials.gov identifier: NCT00176592.
Conclusion Iterative and weekly injections of macrocyclic GBCAs are not associated with T1 signal increase in the DN and GP of MS patients. These results would suggest a no gadolinium accumulation in the brain using macrocyclic GBCA even after several close injections and promote the use of a macrocylcic GBCA rather than linear agents for MS patients.
Publication date: 1 October 2018 Source:NeuroImage, Volume 179 Author(s): Jaeyeon Yoon, Enhao Gong, Itthi Chatnuntawech, Berkin Bilgic, Jingu Lee, Woojin Jung, Jingyu Ko, Hosan Jung, Kawin Setsompop, Greg Zaharchuk, Eung Yeop Kim, John Pauly, Jongho Lee Deep neural networks have demonstrated promising potential for the field of medical image reconstruction, successfully generating high quality images for CT, PET and MRI. In this work, an MRI reconstruction algorithm, which is referred to as quantitative susceptibility mapping (QSM), has been developed using a deep neural network in order to perform dipole deconvolution, w...
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(University at Buffalo) For decades, clinicians treating multiple sclerosis (MS) have interpreted the appearance of new or expanding brain lesions on magnetic resonance imaging (MRI) scans as a sign that a patient's disease is getting worse. Now, University at Buffalo researchers are finding that it may be the atrophy or disappearance of these lesions into cerebrospinal fluid (CSF) that is a better indicator of who will develop disability.
The radiologically isolated syndrome (RIS) refers to the clinical scenario in which individuals with no symptoms of central nervous system demyelination, who underwent MRI scans for other reasons (e.g., head trauma), have the typical neuroimaging findings of multiple sclerosis (MS).
CONCLUSIONS: MAGNIMS 2016 MRI criteria were superior to McDonald 2010 MRI criteria in specificity, accuracy, and PPV, but inferior in sensitivity and NPV. PMID: 29856160 [PubMed - as supplied by publisher]
Scandinavian Journal of Medicine&Science in Sports, EarlyView.
Acta Neurologica Scandinavica, EarlyView.
Conclusions: A potent and selective S1PR2 ligand TZ59130 was identified in vitro. The radiosynthesis of [11C]TZ59130 was achieved with good radiochemical yield and high purity. The biodistribution study in SD rats indicated [11C]TZ59130 had high uptake (%ID/g) in the kidney at 5 min and fast washout in vivo. Further investigation of [11C]TZ59130 on streptozotocin (STZ)-induced diabetic rats is ongoing in our laboratory. Research support: National Multiple Sclerosis Society: #RG150705331, Department of Energy: #DESC0008432.
Conclusions: Our data show that neuroinflammation induced by the copper chelator cuprizone resulted in a significant increase in the uptake of both [11C](R)PK11195 and [11C]DPA713. The EDTA demonstrated a significant change in influx rate during cuprizone-induced neuroinflammation which may be attributed to changes in the BBB permeability, but may also be a result of changes in blood flow.