MRI evidence of acute inflammation in leukocortical lesions of patients with early multiple sclerosis

Conclusions: The presence of enhancing lesions affecting the cortex and adjacent white matter, although transient and not frequent, suggests that at least some cortical lesions are related to blood–brain barrier disruption. Our data support the concept that there may be an acute inflammatory phase in the development of leukocortical MS lesions. Clinicaltrials.gov identifier: NCT00176592.
Source: Neurology - Category: Neurology Authors: Tags: MRI, Multiple sclerosis ARTICLE Source Type: research

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Conclusions We propose a new methodology to facilitate the segmentation of WM and cortical MS lesions at 7 T MRI, our approach uses a single MP2RAGE scan and may be of special interest to clinicians and researchers.
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
(TechLink) VA funded researchers develop and patent protein biomarkers blood test technology for patients with multiple sclerosis, which could replace more costly tests for diagnosing a relapse, ie, an MRI scan.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 2 May 2019Source: NeuroImage: ClinicalAuthor(s): Paul Schmidt, Viola Pongratz née Biberacher, Pascal Küster, Dominik Meier, Jens Wuerfel, Carsten Lukas, Barbara Bellenberg, Frauke Zipp, Sergiu Groppa, Philipp G. Sämann, Frank Weber, Christian Gaser, Thomas Franke, Matthias Bussas, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark MühlauAbstractLongitudinal analysis of white matter lesion changes on serial MRI has become an important parameter to study diseases with white-matter lesions. Here, we build on earlier work on cross-sectional lesion segmentation; we present...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusion Although GWAS contributed insight into the utility of the genotype biomarker to treatment selection, adequately powered prospective studies will be required before clinical application of pharmacogenomics can become a reality. Genotype and phenotype assessment should be facilitated by the availability of detailed molecular analyses and data integration. Careful assessment of prospective GWAS data is essential to integrate findings into the clinical decision-making process, and thereby optimizing the treatment of patients with psoriasis in the future. Author Contributions BY, NG, and WY performed the project. ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Alwin Kamermans, Merel Rijnsburger, Ananya Chakraborty, Susanne van der Pol, Helga E. de Vries† and Jack van Horssen*† Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by the presence of focal demyelinated plaques. Sufficient clearance of myelin and cellular debris is one of the requirements for proper tissue repair and remyelination. The mechanisms underlying the clearance of ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we analyzed the metabolic profiling of fecal samples from SLE patients and healthy controls based on ultra-high-performance liquid chromatography equipped with mass spectrometry for exploring the potential biomarkers of SLE. The results showed that 23 differential metabolites and 5 perturbed pathways were identified between the two groups, including aminoacyl-tRNA biosynthesis, thiamine metabolism, nitrogen metabolism, tryptophan metabolism, and cyanoamino acid metabolism. In addition, logistic regression and ROC analysis were used to establish a diagnostic model for distinguishing SLE patients from healthy ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Hugo Barcenilla1*†, Linda Åkerman1†, Mikael Pihl2, Johnny Ludvigsson1,3 and Rosaura Casas1 1Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden 2Core Facility, Flow Cytometry Unit, Linköping University, Linköping, Sweden 3Crown Princess Victoria Children's Hospital, Region Östergötland, Linköping, Sweden Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin producing β-cells. The time from onset of islet autoimmunity to m...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. Introduction Over the last few years there has been growing interest in th...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Patients with isolated thalamic atrophy were at a higher risk for not reaching 2-year NEDA-3 and for EDSS increase than patients with no identified brain atrophy. The groups were clinically indistinguishable. A single measurement of thalamic and whole brain atrophy could help identify patients needing most effective therapies from early on. Introduction The quantification of brain atrophy by MRI has become an increasingly important part of evaluating neurodegeneration in MS (1, 2). Atrophy measures can reflect the damage on the central nervous system (CNS) caused by the pathological processes of the dis...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF. Introduction Cerebrospinal fluid (CSF) analysis is supportive of the diagnosis of many neurological diseases. CSF protein concentrations constitute a mainstay of CSF analysis. Despite age- and sex-dependent cut-offs (1–4), considerable interindividual variance may lower the diagnostic value of CSF protein concentrations. We aimed to reduce variance of CSF protein concentrations and, hence, to increase their diagnostic value by considering brain volumes derived from magne...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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