MRI evidence of acute inflammation in leukocortical lesions of patients with early multiple sclerosis
Conclusions: The presence of enhancing lesions affecting the cortex and adjacent white matter, although transient and not frequent, suggests that at least some cortical lesions are related to blood–brain barrier disruption. Our data support the concept that there may be an acute inflammatory phase in the development of leukocortical MS lesions. Clinicaltrials.gov identifier: NCT00176592.
CONCLUSIONS: Synthetic and conventional phase-sensitive inversion recovery have a sensitivity similar to that of leukocortical MS lesions. The detected leukocortical lesions are associated with cognitive dysfunction and thus provide clinically relevant information, which encourages assessment of cortical MS involvement at conventional field strengths.
CONCLUSIONS: Because all enhancing lesions were associated with new lesions on unenhanced imaging and progression was only evident in 24% of patients, in patients with relapsing-remitting MS, it is reasonable to consider reserving contrast for only those patients with evidence of progression on noncontrast MR images.
Publication date: Available online 13 November 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): C. Vinciguerra, A. Giorgio, J. Zhang, I. Di Donato, M.L. Stromillo, R. Tappa Brocci, A. Federico, M.T. Dotti, N. De StefanoAbstractBackgroundPeak width of skeletonized mean diffusivity (PSMD) is a novel and fully automated, MRI biomarker, which has shown clinical relevance in cerebral small vessel diseases (SVD). We aimed here to assess PSMD levels across the brain of patients with multiple sclerosis (MS), in comparison to normal controls (NC) and patients with CADASIL, a genetically defined form of severe SVD.Meth...
ConclusionsStudies of EAE in mice suggest that SCFAs may play a role in the development and progression of EAE, but so far this has not been confirmed in humans. An aberrant gut microbiota in MS patients has been reported to be differentially abundant compared with healthy controls, although with little consistency in the bacterial taxa. Further investigations are required to elucidate the involvement of the gut microbiota and its metabolites, including potential beneficial effects of SCFAs, in the development and course of MS.This article is protected by copyright. All rights reserved.
Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes,...
ConclusionFamilial MS cases are more likely to have relapsing ‐remitting MS than a progressive course compared to sporadic MS cases. Secondly, we find that within MS families, first‐degree relatives are likely to have the same MS course, but we do not find that they are diagnosed at the same age.This article is protected by copyright. All rights reserved.
Publication date: Available online 5 November 2018Source: NeuroImage: ClinicalAuthor(s): Haike Zhang, Esther Alberts, Viola Pongratz, Mark Mühlau, Claus Zimmer, Benedikt Wiestler, Paul EichingerAbstractMagnetic resonance imaging (MRI) scans play a pivotal role in the evaluation of patients presenting with a clinically isolated syndrome (CIS), as these may depict brain lesions suggestive of an inflammatory cause. We hypothesized that it is possible to predict the conversion from CIS to multiple sclerosis (MS) based on the baseline MRI scan by studying image features of these lesions.We analyzed 84 patients diagnosed wi...
ConclusionsA significant correlation was established between RNFL thickness and progression of neurodegeneration in MS patients with no regard to history of ON. RNFL thickness may be considered a MS biomarker and potential diagnostic tool for assessment of disease progression.
ConclusionsOur results indicate effects of IFN ‐beta treatment on cerebellar, cortical and subcortical neuronal function. Moreover, more severe fatigue and depression in untreated patients seem to be associated with reduced neuronal activity in left posterior cingulate cortex and left superior temporal cortex, respectively.
ConclusionsWe identified high diversity in DI development within the cohort around MS diagnosis. Socio ‐demographic and work disability characteristics differed between the trajectories. This broader information of the economic situation is important to convey to patients.