Affective prosody in frontotemporal dementia: The importance of "pitching it right"
"It's not what you said; it's how you said it!" How many times have you said or heard that while interacting with a family member or colleague? It is clear that tone of voice (modulations in pitch, loudness, and rhythm of speech, together called prosody) conveys a great deal of intent and emotion in nearly every exchange. Imagine that your spouse's response to a very special birthday gift is "I've never seen anything like it," spoken in a completely monotone voice. You would not be able to tell if he or she loves it or hates it. On the flip side, suppose you say to your spouse, lovingly, "I can hardly believe we have been married for 20 years." But she thinks you sound angry when you say that, so she retorts that she is happy to divorce you to put you out of your misery. As reported by Nevler et al.1 in this issue of Neurology®, people with the behavioral variant of frontotemporal dementia (bvFTD) often have severe impairments in expression of emotion through affective prosody. They also often have trouble understanding affective prosody in others.2 These deficits can lead to frequent misinterpretation and failures of communication. Deficits in prosody expression and comprehension are not specific to bvFTD. Survivors of right middle cerebral artery stroke3,4 and people with autism,5 schizophrenia,6 and Parkinson disease7 also can have marked impairment in affective prosody recognition or production.
In conclusion, our data confirm t-α-synuclein and p-α-synuclein as robust biomarkers for sCJD and indicate the potential use of col orimetric t-α-synuclein ELISAs for differential diagnosis of dementia types.
AbstractNumerous attempts to develop an early diagnosis of Parkinson ’s disease (PD) by searching biomarkers in biological fluids were unsuccessful. The drawback of this methodology is searching markers in patients at the clinical stage without guarantee that they are also characteristic of either preclinical stage or prodromal stage (preclinical–prodromal stage) . We attempted to upgrade this methodology by selecting only markers that are found both in patients and in PD animal models. HPLC and RT-PCR were used to estimate the concentration of amino acids, catecholamines/metabolites in plasma and gene expressi...
AbstractThe term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation. Due to the complex interactions and intersection of proteostasis pathways, exposure to stress conditions may lead to a disruption of the entire network. Incorrect protein folding and/or modifications during protein synthesis results in inactive or toxic proteins, which may overload degradation mechanisms. Further, a disruption of autophagy and the endoplasmic reticul...
In conclusion, insular sub-regional atrophy, particularly the anterior dorsal region, may contribute to cognitive and neuropsychiatric deficits in neurodegeneration. Our results support anterior insular cortex vulnerability and convey the differential involvement of th e insular sub-regions in functional deficits in neurodegenerative diseases.
ConclusionsWe report the first clinical description of an association between autistic symptoms and Greig cephalopolysyndactyly syndrome in two members of the same family with the same genetic point deletion. Further research is required in order to draw an accurate conclusion regarding the association between Greig cephalopolysyndactyly syndrome and autism.
Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fitted.
Previously housebound patients are now able to walk more freely as a result of electrical stimulation to their spines. Researchers say the small trial of the treatment has gone 'beyond their wildest dreams'.
The FDA wants to underscore our continued confidence in the safety and effectiveness of the vaccines that are highly successful at preventing – in some cases, nearly eradicating – preventable diseases. Large well-designed studies have confirmed the safety and effectiveness of the MMR vaccine and have demonstrated that administration of the vaccine is not associated with the development of autism. MMR vaccine has been approved in the U nited States for nearly 50 years to prevent measles, mumps and rubella (also known as German Measles). As a result of its use, measles and rubella were completely eradicated in th...
Two studies, taken together, imply that sequencing can identify a genetic cause for ultrasound abnormalities in roughly 10 percent of cases.
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 4/30/2019 4:00:00 PM