High-dose thiotepa, busulfan, cyclophosphamide and autologous stem cell transplantation as upfront consolidation for systemic non-Hodgkin lymphoma with synchronous central nervous system involvement
Systemic non-Hodgkin lymphoma with synchronous central nervous system (CNS) involvement traditionally carries a poor prognosis. We found encouraging results with the use of high-dose chemotherapy and autologous stem cell transplantation as consolidation for patients in first complete remission. CNS-directed conditioning with a thiotepa-based regimen might reduce the incidence of relapse and improve the outcomes in this population.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: David Qualls, Andrew Sullivan, Shuli Li, Andrew M. Brunner, Kerry Collier, Ephraim Hochberg, Philippe Armand, Tracy T. Batchelor, Yi-Bin Chen, Zachariah DeFilipp Source Type: research
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