Do SGLT2 Inhibitors ’ Heart Failure Benefits Involve Sodium-hydrogen Exchanger? Do SGLT2 Inhibitors ’ Heart Failure Benefits Involve Sodium-hydrogen Exchanger?

Sodium-glucose cotransporter 2 (SGLT2) inhibitors may reduce cardiovascular events via interaction with the sodium-hydrogen exchanger, researchers suggest.Reuters Health Information
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pathology & Lab Medicine News Source Type: news

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Medmastery video helps identify the features of cardiac failure on the chest X-ray. Evaluation of the three stages of failure including vascular redistribution; interstitial oedema and alveolar oedema The post CXR Essentials: The Failing Heart appeared first on Life in the Fast Lane.
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Cardiology Medmastery Respiratory alveolar edema CXR Heart failure interstitial edema pulmonary oedema Source Type: blogs
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was suffic...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsHere we report the case of a patient with hereditary cardiac amyloidosis associated with a Pro24Ser mutation in transthyretin, which is the first case reported in Japan. Technetium pyrophosphate scintigraphy was extremely useful for definitive diagnosis. Thus, we propose that the nuclear imaging technique should be taken into account even for an exploratory diagnosis of transthyretin cardiac amyloidosis.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Authors: Guo M, Luo J, Zhao J, Shang D, Lv Q, Zang P Abstract BACKGROUND Circulating microRNAs (miRNAs) are emerging as novel biomarkers for detecting cardiovascular diseases. Here, circulating miR-133a and miR-221 were investigated as potential diagnostic biomarkers for heart failure (HF) patients, particularly in elderly patients. MATERIAL AND METHODS A total of 94 elderly HF patients (mean age=77.4 years old) and 31 healthy controls (age- and sex-matched) participated in this study. Plasma NT-proBNP levels were measured using an electrochemiluminescence immunoassay, and circulating miR-133a and miR-221 levels we...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
(MedPage Today) -- This week's topics also include prostatectomy versus watchful waiting, and flu vaccines and heart failure
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
Publication date: Available online 14 December 2018Source: Journal of Veterinary CardiologyAuthor(s): A. Kalyanasundaram, N. Li, B.J. Hansen, J. Zhao, V.V. FedorovAbstractThe sinoatrial node (SAN) is the primary pacemaker in canine and human hearts. The SAN in both species has a unique three-dimensional heterogeneous structure characterized by small pacemaker myocytes enmeshed within fibrotic strands, which partially insulate the cells from aberrant atrial activation. The SAN pacemaker tissue expresses a unique signature of proteins and receptors that mediate SAN automaticity, ion channel currents, and cell-to-cell communi...
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research
Publication date: Available online 14 December 2018Source: Revista Clínica Española (English Edition)Author(s): J. Jacob, L. Llauger, V. Gil, P. Javaloyes
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: Available online 14 December 2018Source: Pharmacology &TherapeuticsAuthor(s): Julian Mustroph, Simon Lebek, Lars S. Maier, Stefan NeefAbstractEthanol can acutely and chronically alter cardiomyocyte and whole-organ function in the heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic abuse can induce heart failure. However, the molecular mechanisms of ethanol toxicity in the heart are incompletely understood.In this review, we summarize the current mechanistic knowledge on cardiac ethanol toxicity, with a focus on druggable pathways. Ethanol effects on excitation...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: November 2018Source: Revista Portuguesa de Cardiologia (English Edition), Volume 37, Issue 11Author(s): Sofia Isabel Jardim, Luís Ramos dos Santos, Inês Araújo, Filipa Marques, Patrícia Branco, Augusta Gaspar, Cândida FonsecaAbstractHeart failure is a disease with high direct and indirect costs. Current treatment includes drugs that alter disease progression and drugs that to improve symptoms. Loop diuretics are the cornerstone of congestion relief for acute management, as well as for chronic stabilization. In heart failure patients, maximal diuretic response is reduced by...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Publication date: November 2018Source: Revista Portuguesa de Cardiologia (English Edition), Volume 37, Issue 11Author(s): João Filipe Carvalho, Adriana Belo, Kisa Congo, David Neves, Ana Rita Santos, Bruno Piçarra, Ana Filipa Damásio, José Aguiar, on behalf of the investigators of the Portuguese Registry on Acute Coronary Syndromes (ProACS)AbstractIntroductionA low-risk GRACE score identifies patients with a lower incidence of major cardiac events, however it can erroneously classify patients with severe coronary artery disease as low-risk. We assessed the prevalence, clinical outcomes and predi...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
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