Efficacy and safety of a fixed ‐dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third molar extraction

ConclusionThis study demonstrated clinically relevant superiority of ibuprofen/caffeine over monotherapy with ibuprofen in patients with acute dental pain. All treatments were well tolerated. SignificanceThis trial showed superior efficacy of 400/100 mg ibuprofen/caffeine, compared to 400 mg ibuprofen alone, for treating acute pain, reflecting that caffeine is an effective analgesic adjuvant. Data on efficacy of 400 mg ibuprofen combined with caffeine for the treatment of acute pain were not available yet.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research