Effect of acute and subchronic stress on electrical activity of basolateral amygdala neurons in conditioned place preference paradigm: An electrophysiological study.

Effect of acute and subchronic stress on electrical activity of basolateral amygdala neurons in conditioned place preference paradigm: An electrophysiological study.
Behav Brain Res. 2017 Aug 07;:
Authors: Fatahi Z, Zibaii MI, Haghparast A
Abstract
The basolateral amygdala (BLA) plays a critical role in the neural circuitry of stress and mediates the effects of stress on memory related processes. Moreover, this area has an important role in drug-seeking and relapse of approach behavior to drug-associated cues. Therefore, in the present study, we aimed to investigate the effects of acute and subchronic stress in saline- and/or morphine-treated rats in conditioned place preference paradigm on the neural activity in the BLA. Male Wistar rats were divided into two saline- and morphine-treated supergroups. Each supergroup contained control, acute stress (AS) and subchronic stress (SS) groups. In all of the groups, conditioned place preference paradigm was done and thereinafter the spontaneous firing activity was recorded by in vivo single unit recording for 20min. Results showed that in saline-and/or morphine-treated animals, both AS and SS increased neural activity of projection neurons and this increase in morphine-treated animals was more considerable than that of saline-treated animals. Besides, firing rate of interneurons in both supergroups decreased during AS and SS. Decrease of interneurons activity after application of SS in morp...

Source: Behavioural Brain Research - August 7, 2017 Category: Neurology Authors: Fatahi Z, Zibaii MI, Haghparast A Tags: Behav Brain Res Source Type: research