Platelet activation and erythrocyte lysis during brief exposure of blood to pathophysiological shear stress in vitro.

CONCLUSIONS: Our experimental approach mimics conditions in severe arterial stenosis or a mechanical heart valve. It could be a valuable aid in the development of novel drugs to treat arterial thrombosis and in the design of heart valves.
PMID: 28800323 [PubMed - as supplied by publisher]

Source: Clinical Hemorheology and Microcirculation - August 11, 2017 Category: Hematology Authors: Majumdar S, Patil CN, Ladner-Threadgill T, Randolph E, Burgreen GW, Kermode JC Tags: Clin Hemorheol Microcirc Source Type: research