Gastrointestinal Manifestations of STAT3-Deficient Hyper-IgE Syndrome

ConclusionThe majority of AD-HIES subjects develop GI manifestations as part of their disease. Most notable are the symptoms and radiologic findings of GI dysmotility, as well as significant eosinophilic infiltration, concerning for a secondary eosinophilic esophagitis. These findings suggest that theSTAT3 pathway may be implicated in a new mechanism for the pathogenesis of several GI disorders.

http://link.springer.com/10.1007/s10875-017-0429-z

Source: Journal of Clinical Immunology - August 13, 2017 Category: Allergy & Immunology Source Type: research