Chapter Six Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases

Publication date: 2017 Source:International Review of Neurobiology, Volume 135 Author(s): Chong Gao, Jiangang Shen Adult neurogenesis plays the important roles in animal cognitive and emotional behaviors. Abnormal proliferation and differentiation of neural stem cells (NSCs) usually associate with the neural dysfunctions induced by different brain disorders. Therefore, targeting neurogenic factors could be a promoting strategy for neural regeneration and brain repair. Importantly, epidemiological studies suggest metabolism disorders like diabetes and obesity significantly increase the risk of neurological and psychiatric diseases. A large number of studies indicate that metabolic factors could serve as the modulators to adult neurogenesis, providing the potentials of metabolic factors to regulate NSCs growth and neural regeneration therapy. This chapter reviews the current studies on the roles of metabolic factors in modulating adult neurogenesis and evaluates the potentials of Chinese Herbal Medicine (CHM) for the treatment of neurological or psychiatric disorders by targeting the metabolic factors. Traditional Chinese Medicine (TCM) including CHM and acupuncture is now widely applied for the treatment of metabolic diseases, and neurological diseases in Asia, because its’ therapeutic principles meet the multiple targets and complexity characteristics of most neurological disorders. Different studies indicate that there are many active compounds perform the regulations...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research

Related Links:

(CNN) — Death rates from liver cancer increased 43% for American adults from 2000 to 2016, according to a report released Tuesday by the US Centers for Disease Control and Prevention’s National Center for Health Statistics. The increase comes even as mortality for all cancers combined has declined. Liver cancer death rates increased for both men and women 25 and older, as well as white, black and Hispanic people. Only Asians and Pacific Islanders saw a decrease in mortality from liver cancer. The rise in mortality doesn’t mean that liver cancer is deadlier than before, according to Dr. Jiaquan Xu, the aut...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Cancer Liver Cancer Source Type: news
AbstractPurpose of ReviewObesity and type 2 diabetes (T2D) are closely linked metabolic diseases. Most individuals with T2D are overweight or obese, which raises their cardiovascular risk. The etiology of both diseases is multifaceted, thus requiring a multidisciplinary approach to control them. This review describes the most effective multidisciplinary approach to weight management in patients with T2D in real-world clinical practice.Recent FindingsWeight management programs in real-world clinical settings lead to long-term weight loss for up to 5  years.SummaryMultidisciplinary approach to manage obesity and T2D thr...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewThis review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats orPsammomys obesus (P.obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal model closely mimics phenotypic and pathophysiological resemblance with human populations.Recent FindingsThe physiological status and biochemical composition inP.obesus can be manipulated effectively by controlling its nutritional intake, making it a natural model for cardiovascular and diabetic research. ...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Blood lipid profile might be one of the possible links between subfertility and later CVD Related items fromOnMedica Early periods linked to heightened cardiovascular risk Gestational diabetes raises long-term CVD risk Waist size predicts type 2 diabetes risk Obesity associated with worse mortality and higher CVD risk Child type 2 diabetes is a ‘wake-up call’ to the nation
Source: OnMedica Latest News - Category: UK Health Source Type: news
Government ’s updated plan has bold ambitions, now it needs urgent implementation, says Cancer Research UK Related items fromOnMedica Preventing type 2 diabetes Wider approach needed to boost public health Health 'time-bomb' warning from severely obese children GPs should lead on weight management advice to children Government needs to stop prioritising car to tackle childhood obesity
Source: OnMedica Blogs - Category: General Medicine Source Type: blogs
Conditions:   Obesity;   Diabetes Mellitus, Type 2 Interventions:   Drug: JNJ-64565111 Dose Level 1;   Drug: JNJ-64565111 Dose Level 2;   Drug: JNJ-64565111 Dose Level 3;   Drug: Placebo Sponsor:   Janssen Research & Development, LLC Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was not designed to explain whether supplementing with vitamin D will protect against asbestosis. This new research also does not examine if taking vitamin D will slow down the progression of existing ILD. Still, there are a lot of good reasons to pay attention to the sunshine vitamin. Regardless of whether a person has been exposed to asbestos, no one should ignore very low vitamin D levels. People already diagnosed with an asbestos-related cancer, may benefit from a quick check of vitamin D levels. According to the medical literature, up to 80 percent of people with cancer may be vitamin D deficient. People ca...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 010 Peer Reviewer: Dr Jennifer Ho, ID physician QLD, Australia You are an ED doc working in Perth over schoolies week. An 18 yo man comes into ED complaining of fever, rash a “cracking headache” and body aches. He has just hopped off the plane from Bali where he spent the last 2 weeks partying, boozing and running amok. He got bitten by “loads” of mosquitoes because he forgot to take insect repellent. On e...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine arthralgia dengue fever rash Source Type: blogs
AbstractFor many years, obesity was believed to be a condition of overeating that could be resolved through counseling and short-term drug treatment. Obesity was not recognized as a chronic disease until 1985 by the scientific community, and 2013 by the medical community. Pharmacotherapy for obesity has advanced remarkably since the first class of drugs, amphetamines, were approved for short-term use. Most amphetamines were removed from the obesity market due to adverse events and potential for addiction, and it became apparent that obesity pharmacotherapies were needed that could safely be administered over the long term....
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Obesity is a multifaceted, chronic, low-grade inflammation disease characterized by excess accumulation of dysfunctional adipose tissue. It is often associated with the development of cardiovascular (CV) disorders, insulin resistance and diabetes. Under pathological conditions like in obesity, adipose tissue secretes bioactive molecules called ‘adipokines’, including cytokines, hormones and reactive oxygen species (ROS). There is evidence suggesting that oxidative stress, in particular, the ROS imbalance in adipose tissue, may be the mechanistic link between obesity and its associated CV and metabolic complicat...
Source: Journal of Endocrinology - Category: Endocrinology Authors: Tags: Review Source Type: research
More News: Acupuncture | Brain | China Health | Complementary Medicine | Diabetes | Eating Disorders & Weight Management | Endocrinology | Epidemiology | Gastroschisis Repair | Herbs | Neurology | Neuroscience | Obesity | Psychiatry | Stem Cell Therapy | Stem Cells | Study