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Chapter Six Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases

Publication date: 2017 Source:International Review of Neurobiology, Volume 135 Author(s): Chong Gao, Jiangang Shen Adult neurogenesis plays the important roles in animal cognitive and emotional behaviors. Abnormal proliferation and differentiation of neural stem cells (NSCs) usually associate with the neural dysfunctions induced by different brain disorders. Therefore, targeting neurogenic factors could be a promoting strategy for neural regeneration and brain repair. Importantly, epidemiological studies suggest metabolism disorders like diabetes and obesity significantly increase the risk of neurological and psychiatric diseases. A large number of studies indicate that metabolic factors could serve as the modulators to adult neurogenesis, providing the potentials of metabolic factors to regulate NSCs growth and neural regeneration therapy. This chapter reviews the current studies on the roles of metabolic factors in modulating adult neurogenesis and evaluates the potentials of Chinese Herbal Medicine (CHM) for the treatment of neurological or psychiatric disorders by targeting the metabolic factors. Traditional Chinese Medicine (TCM) including CHM and acupuncture is now widely applied for the treatment of metabolic diseases, and neurological diseases in Asia, because its’ therapeutic principles meet the multiple targets and complexity characteristics of most neurological disorders. Different studies indicate that there are many active compounds perform the regulations...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research

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CONCLUSIONS The obese type 2 diabetic patients presented a disturbed adipokine profile, which seems to be an important link between obesity and T2D. The future studies concerning the question if regulating of adipokines' concentrations could be a promising approach for managing metabolic disorders seem to be well-grounded. PMID: 29049270 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
(Natural News) The obesity-related diabetes disaster continues unabated in the United Kingdom, triggering a rash of amputations that may be causing premature death in 80 percent of patients. As reported by the U.K.’s Daily Mail, the obesity epidemic is feeding into a record-high 160 amputations per week, according to the most recent health figures, which...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
ConclusionsThere were no clinically relevant differences in safety or PK/PD of NG associated with nasal congestion or concomitant administration of nasal decongestant, suggesting that NG can be used to treat severe hypoglycaemia in people experiencing nasal congestion.
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Funding Opportunity PA-18-330 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for investigator-initiated clinical trials within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to be conducted at no more than two clinical research centers. NIDDK is committed to improving the health of people with diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic and hematologic diseases. Applications for clinical trials submitted under this FOA should be hy...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Publication date: December 2017 Source:Food Policy, Volume 73 Author(s): Yevgeniy Goryakin, Pablo Monsivais, Marc Suhrcke We take advantage of four different cross-country datasets containing data on 78 countries for the period 1999–2014, in order to assess the relationship of carbonated soft drinks’ sales, as well as their prices, with body mass index (BMI), overweight, obesity and diabetes. Using an ecological study design and multivariate regression longitudinal estimation approaches, we find that carbonated soft drink sales were significantly positively related to BMI, overweight and obesity – but on...
Source: Food Policy - Category: Food Science Source Type: research
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Obesity and metabolic syndrome is considered an epidemic in Western societies. An adult is considered to be obese with a BMI of 30 or above. Obesity imposes a significant human burden of disease, mortality, social exclusion and poor quality of life. It is closely associated with multiple comorbidities including type 2 diabetes, coronary heart disease, and poor health status, and has a substantial human cost by contributing to the onset of disease and premature mortality. Surgical interventions are significantly more effective than non-surgical therapies for the treatment of severe obesity, reduction of cardiovascular morbi...
Source: Surgery (Medicine Publishing) - Category: Surgery Authors: Tags: Oesophagus and stomach Source Type: research
Conclusions Qualitative analysis identified barrier and strategy themes that may assist nutrition and dietetics practitioners working with tribal/indigenous communities, tribal college educators and health specialists, and tribal community health workers who target health and dietary intake of American Indian and Alaskan Native students.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Obesity is associated with elevated risks of adverse health outcomes and is an important risk factor for cardiovascular diseases, diabetes, some cancers.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsThere was no correlation between excised stomach size in laparoscopic sleeve gastrectomy and postoperative weight loss (percent of excess body weight lost) or change in BMI. Male gender, diabetes, and increasing patients ’ age correlated with larger excised stomach size. Initial BMI and having histological gastritis did not correlate with excised stomach size.
Source: Obesity Surgery - Category: Surgery Source Type: research
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