A Survival Analysis of Subjects with Transthyretin Amyloid Cardiomyopathy From the Transthyretin Amyloidosis Outcomes Survey

Introduction: Transthyretin cardiomyopathy (ATTR-CM) is a rare, progressively fatal disease caused by accumulation of misfolded TTR amyloid fibrils in the heart, leading to restrictive cardiomyopathy and heart failure. The structural instability of the TTR tetramer can occur due to genetic mutations of the gene encoding TTR protein or can be associated with aging (wild-type). The Transthyretin Amyloidosis Outcomes Survey is an ongoing, longitudinal, international registry of individuals diagnosed with or at risk (carrying a mutation) for TTR amyloidosis.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research