Hydroxychloroquine-Mediated Cardiotoxicity with a False Positive 99M-Technetium Labeled Pyrophosphate Scan for Amyloidosis

Introduction: Cardiac amyloidosis is an infiltrative process most commonly caused by abnormal deposition of precursor proteins from monoclonal light chain (AL) or transthyretin (hereditary ATTRmt or wild-type ATTRwt). ATTRwt is increasingly recognized as an important cause of heart failure, especially in those over age 60, but diagnosis is challenging and historically often required cardiac biopsy. Bone scintigraphy using 99mtechnetium-labeled pyrophosphate (99mTc-PYP) has been reported to have high specificity at 99% for ATTR in studies to date.

Source: Journal of Cardiac Failure - August 1, 2017 Category: Cardiology Authors: Ian C. Chang, John P. Bois, Melanie C. Bois, Joseph J. Maleszewski, Geoffrey B. Johnson, Martha Grogan Source Type: research