The Increased Mortality Risk Associated with Metolazone in Acute Heart Failure is Mediated by Worsening Renal Function and Electrolyte Disturbances

Background: Current guidelines recommend the addition of a thiazide when diuresis is inadequate during acute decompensated HF (ADHF) treatment; however this is based on limited data. Given that dual segmental nephron blockade may have harmful effects, we set out to determine the relationship between metolazone use during ADHF and mortality utilizing propensity score adjustment. Methods: Patients admitted to 3 hospitals employing a common EMR with a discharge diagnosis of HF and who received IV diuretics within the first 7 days were studied.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research