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Fibroblast Growth Factor 15 Deficiency Increases Susceptibility but does not Improves Repair to Acetaminophen-induced Liver Injury in Mice

In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Liver, Pancreas and Biliary Tract Source Type: research

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Details the increased rates of Hepatitis C and how they correlate to the opioid epidemic by looking at West Virginia, which has the highest rates of overdose deaths and new hepatitis B and C infections in the country. Because those infected with hepatitis often do not display symptoms immediately, the disease can go untreated for years, leading eventually to end-stage liver disease. This is one among many diseases that are rising in the midst of the opioid epidemic, and although there is a treatment for it, for many it is not affordable. (May require subscription to view full article.)
Source: News stories via the Rural Assistance Center - Category: Rural Health Source Type: news
Did you know that by the time you’re 50, you could have almost five pounds of toxins trapped inside your cells, tissue and organs? For millions of years, we had clean air and pure water. But in the past hundred years, our environment has changed faster than we can evolve with it. We weren’t designed to live in a modern world of manmade chemicals, toxins and pollutants. That’s why purging your body of pollutants is more important today than ever. Environmental toxins have become a major health threat. These toxins have linked with many of today’s chronic diseases including: • Cancer • Di...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
BURLINGTON (CBS) – Doctors at Lahey Hospital told Matt Higgins a new liver was his only option for survival as chronic liver disease ravaged the Seabrook, New Hampshire man’s body. “My energy levels, I was down to nothing. I could barely walk a 100 yards without having to stop. I was jaundiced, completely yellow,” Higgins told WBZ-TV. When the call came that a liver transplant was available from a 24-year-old donor who had died from an opioid overdose, Higgins said, he did not hesitate. He immediately accepted it. “Being as sick as I was, of course I said yes. I’ll take anything that&rsq...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Confronting The Crisis Louisa Moller opioid crisis Organ Donation Source Type: news
In a new study of the leading causes of death in the U.S., researchers say that opioids have contributed to a shortening of life expectancy. Scientists from the Centers for Disease Control and Prevention report in JAMA that while life expectancy in the U.S. increased overall from 2000 to 2015, that improvement was blunted by deaths from opioid overdoses. (According to other recent research, deaths from opioid overdoses nearly doubled in the U.S. from 2009 to 2015.) The life expectancy for people born in 2015 increased by two years compared to people born in 2000, from 76 years to 78. Much of that gain was due to decreases ...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized are opioids painkillers drug addiction Drugs leading causes of death opioid addiction opioid epidemic opioid overdose opioid overdoses opioid pain killers what are opioids what is the leading cause of death Source Type: news
In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Liver, Pancreas and Biliary Tract Source Type: research
Contributors : Julian Krauskopf ; Jos KleinjansSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThe dataset comprises of circulating miRNAs in human subjects with various types of liver impairments. In our study, we analyzed a total 48 serum samples from a group of 42 subjects that included subjects with accidental acetaminophen overdose (APAP), hepatitis B infection (HBV), liver cirrhosis (LC) and type 2 diabetes mellitus (T2DM) subjects with alanine amino transference (ALT) elevation. As a control 16 sex and age matched healthy controls from subjects with no evidence of liver dis...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusion: These results demonstrate that 2‐O‐sulfated domains in syndecan‐1 HS halt disease progression and promote liver repair by enhancing hepatocyte survival in APAP‐induced liver injury. We propose that syndecan‐1 is a critical endogenous factor that controls the balance between pro‐survival signaling and apoptosis in hepatocytes in APAP liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Liver Injury and Regeneration Source Type: research
What are you doing to maintain vigor as long as feasible?  Fries wrote a classic article in the NEJM – Aging, Natural Death and the Compression of Morbidity. Fries argues that chronic disease is our foe – avoiding chronic disease allows us to wait longer until we develop morbidity.  The ideal situation is excellent health until 90 then die in your sleep. How do we do that?  Unfortunately, some people develop chronic diseases that we do not know how to prevent.  However, any physician will tell you that much chronic disease develops because of lifestyle choices.  Here is my list of lifes...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
by Julian Krauskopf, Theo M. de Kok, Shelli J. Schomaker, Mark Gosink, Deborah A. Burt, Patricia Chandler, Roscoe L. Warner, Kent J. Johnson, Florian Caiment, Jos C. Kleinjans, Jiri Aubrecht MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. We were first to demonstrate that next-generation sequencing analysis of serum from human subjects with acetaminophen-induced liver injury revealed a specific signature of circulating miRNAs. We consequently hypothesized that different types of hepatic liver impairments might feature disti...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
People who are addicted to opioids and receiving their medical care in a general health care setting were more than 10 times as likely to die during a four-year period than people without substance abuse problems, UCLA researchers have found. The new study, published in the  Journal of Addiction Medicine, suggests that health care systems should have better infrastructure and training for primary care physicians to diagnose and treat opioid use disorder, a condition that includes addiction to both prescription and illicit opioids.UCLAYih-Ing HserThe study, led by Yih-Ing Hser, professor of psychiatry and behavioral sc...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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