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Fibroblast Growth Factor 15 Deficiency Increases Susceptibility but does not Improves Repair to Acetaminophen-induced Liver Injury in Mice

In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Liver, Pancreas and Biliary Tract Source Type: research

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Contributors : Julian Krauskopf ; Jos KleinjansSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThe dataset comprises of circulating miRNAs in human subjects with various types of liver impairments. In our study, we analyzed a total 48 serum samples from a group of 42 subjects that included subjects with accidental acetaminophen overdose (APAP), hepatitis B infection (HBV), liver cirrhosis (LC) and type 2 diabetes mellitus (T2DM) subjects with alanine amino transference (ALT) elevation. As a control 16 sex and age matched healthy controls from subjects with no evidence of liver dis...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusion: These results demonstrate that 2‐O‐sulfated domains in syndecan‐1 HS halt disease progression and promote liver repair by enhancing hepatocyte survival in APAP‐induced liver injury. We propose that syndecan‐1 is a critical endogenous factor that controls the balance between pro‐survival signaling and apoptosis in hepatocytes in APAP liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Liver Injury and Regeneration Source Type: research
What are you doing to maintain vigor as long as feasible?  Fries wrote a classic article in the NEJM – Aging, Natural Death and the Compression of Morbidity. Fries argues that chronic disease is our foe – avoiding chronic disease allows us to wait longer until we develop morbidity.  The ideal situation is excellent health until 90 then die in your sleep. How do we do that?  Unfortunately, some people develop chronic diseases that we do not know how to prevent.  However, any physician will tell you that much chronic disease develops because of lifestyle choices.  Here is my list of lifes...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
by Julian Krauskopf, Theo M. de Kok, Shelli J. Schomaker, Mark Gosink, Deborah A. Burt, Patricia Chandler, Roscoe L. Warner, Kent J. Johnson, Florian Caiment, Jos C. Kleinjans, Jiri Aubrecht MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. We were first to demonstrate that next-generation sequencing analysis of serum from human subjects with acetaminophen-induced liver injury revealed a specific signature of circulating miRNAs. We consequently hypothesized that different types of hepatic liver impairments might feature disti...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
People who are addicted to opioids and receiving their medical care in a general health care setting were more than 10 times as likely to die during a four-year period than people without substance abuse problems, UCLA researchers have found. The new study, published in the  Journal of Addiction Medicine, suggests that health care systems should have better infrastructure and training for primary care physicians to diagnose and treat opioid use disorder, a condition that includes addiction to both prescription and illicit opioids.UCLAYih-Ing HserThe study, led by Yih-Ing Hser, professor of psychiatry and behavioral sc...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Advances in treatment and access to care have seen premature deaths from HIV/AIDS and cancer decline dramatically for Americans. However, premature deaths from accidental causes —primarily drug overdoses, chronic liver disease, and suicide—have risen so precipitously that much of the good work on HIV/AIDS and cancer has been, in population terms, negated.
Source: LANCET - Category: Journals (General) Authors: Tags: Editorial Source Type: research
Drug overdoses, liver disease, suicides fuel jump in numbers for whites, U.S. study finds
Source: WebMD Health - Category: Consumer Health News Source Type: news
By JEFF GOLDSMITH Donald Trump’s stunning upset victory has occasioned a lot of searching among political analysts for an underlying explanation for the unexpected turn in voter sentiment. Many point to Trump’s galvanizing support among white working class and middle income Americans in economically depressed regions of the US- particularly Appalachia and the upper middle west “Rust Belt” – as the main factor that put him in office. While the Democrats concentrated on the so-called “coalition of the ascendant”- voter groups like Hispanics and Millennials that are growing, Trump ro...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
Gains in life expectancy in the United States are being eroded at least in part due to the use and misuse of prescribed medications. Earlier this year, the US Centers for Disease Control and Prevention reported that life expectancy for some groups in the United States continues to stagnate. Among middle-aged white women, life expectancy decreased, in large part due to medication overdose, opioid use, and liver disease.
Source: JAMA - Category: Journals (General) Source Type: research
Abstract Treatment for type 1 Gaucher disease (GD1) decreases morbidity from hematological cytopenias, hepatosplenomegaly and bone complications. Consequently, untreated symptomatic patients for study of late outcomes are hard to find. We identified 184 untreated GD1 patients (67.4% Ashkenazi; splenectomy 51.1%) who died between 1950 and 2010. Here, we report confirmed causes of death for these patients compared with the overall US population. Median age of death 66years (2-97years); causes of death (COD) with a high proportional mortality rate (PMR) included malignancies (PMR 1.57), suicide/drug overdose (PMR 3.8...
Source: Blood Cells, Molecules and Diseases - Category: Hematology Authors: Tags: Blood Cells Mol Dis Source Type: research
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