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Fibroblast Growth Factor 15 Deficiency Increases Susceptibility but does not Improves Repair to Acetaminophen-induced Liver Injury in Mice

In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Liver, Pancreas and Biliary Tract Source Type: research

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Abstract Acetaminophen (APAP) overdose is currently the leading cause of acute liver disease, but therapeutic treatment strategies are commonly limited. Although dihydroquercetin (DHQ) is an attractive botanical antioxidant, its protective potential for liver disease remains elusive. The present study investigated the protective effects of DHQ against APAP-induced hepatic cytotoxicity. Primary mouse hepatocytes were treated with different concentrations of DHQ followed by APAP administration. Our data showed that DHQ relieved APAP-induced growth inhibition and lactate dehydrogenase (LDH) release in a dose-dependen...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induc...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
Details the increased rates of Hepatitis C and how they correlate to the opioid epidemic by looking at West Virginia, which has the highest rates of overdose deaths and new hepatitis B and C infections in the country. Because those infected with hepatitis often do not display symptoms immediately, the disease can go untreated for years, leading eventually to end-stage liver disease. This is one among many diseases that are rising in the midst of the opioid epidemic, and although there is a treatment for it, for many it is not affordable. (May require subscription to view full article.)
Source: News stories via the Rural Assistance Center - Category: Rural Health Source Type: news
Did you know that by the time you’re 50, you could have almost five pounds of toxins trapped inside your cells, tissue and organs? For millions of years, we had clean air and pure water. But in the past hundred years, our environment has changed faster than we can evolve with it. We weren’t designed to live in a modern world of manmade chemicals, toxins and pollutants. That’s why purging your body of pollutants is more important today than ever. Environmental toxins have become a major health threat. These toxins have linked with many of today’s chronic diseases including: • Cancer • Di...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
BURLINGTON (CBS) – Doctors at Lahey Hospital told Matt Higgins a new liver was his only option for survival as chronic liver disease ravaged the Seabrook, New Hampshire man’s body. “My energy levels, I was down to nothing. I could barely walk a 100 yards without having to stop. I was jaundiced, completely yellow,” Higgins told WBZ-TV. When the call came that a liver transplant was available from a 24-year-old donor who had died from an opioid overdose, Higgins said, he did not hesitate. He immediately accepted it. “Being as sick as I was, of course I said yes. I’ll take anything that&rsq...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Confronting The Crisis Louisa Moller opioid crisis Organ Donation Source Type: news
In a new study of the leading causes of death in the U.S., researchers say that opioids have contributed to a shortening of life expectancy. Scientists from the Centers for Disease Control and Prevention report in JAMA that while life expectancy in the U.S. increased overall from 2000 to 2015, that improvement was blunted by deaths from opioid overdoses. (According to other recent research, deaths from opioid overdoses nearly doubled in the U.S. from 2009 to 2015.) The life expectancy for people born in 2015 increased by two years compared to people born in 2000, from 76 years to 78. Much of that gain was due to decreases ...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized are opioids painkillers drug addiction Drugs leading causes of death opioid addiction opioid epidemic opioid overdose opioid overdoses opioid pain killers what are opioids what is the leading cause of death Source Type: news
In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Liver, Pancreas and Biliary Tract Source Type: research
Contributors : Julian Krauskopf ; Jos KleinjansSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThe dataset comprises of circulating miRNAs in human subjects with various types of liver impairments. In our study, we analyzed a total 48 serum samples from a group of 42 subjects that included subjects with accidental acetaminophen overdose (APAP), hepatitis B infection (HBV), liver cirrhosis (LC) and type 2 diabetes mellitus (T2DM) subjects with alanine amino transference (ALT) elevation. As a control 16 sex and age matched healthy controls from subjects with no evidence of liver dis...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusion: These results demonstrate that 2‐O‐sulfated domains in syndecan‐1 HS halt disease progression and promote liver repair by enhancing hepatocyte survival in APAP‐induced liver injury. We propose that syndecan‐1 is a critical endogenous factor that controls the balance between pro‐survival signaling and apoptosis in hepatocytes in APAP liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Liver Injury and Regeneration Source Type: research
What are you doing to maintain vigor as long as feasible?  Fries wrote a classic article in the NEJM – Aging, Natural Death and the Compression of Morbidity. Fries argues that chronic disease is our foe – avoiding chronic disease allows us to wait longer until we develop morbidity.  The ideal situation is excellent health until 90 then die in your sleep. How do we do that?  Unfortunately, some people develop chronic diseases that we do not know how to prevent.  However, any physician will tell you that much chronic disease develops because of lifestyle choices.  Here is my list of lifes...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
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