How to prevent ageing: THIS could be the key to staying young and preventing illness

COMBATTING ageing and frailty is as preventable as heart disease and diabetes, scientists have claimed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Roche today announced that the phase III CAPSTONE-2 study assessing the safety and efficacy of baloxavir marboxil in people at high risk of complications from the flu met the study ’s primary objective, and showed superior efficacy in the primary endpoint of time to improvement of influenza symptoms versus placebo The Centers for Disease Control and Prevention (CDC) defines people at high risk for serious flu complications to include adults 65 years of age or older, or thos e who have conditions such as asthma, chronic lung disease, diabetes, or heart disease – for these people, flu can lead to hospitalisation or even death.
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Putting in long hours at the office could make you more likely to get diabetes, heart disease and psychiatric disorders, research suggests.
Source: WebMD Health - Category: Consumer Health News Source Type: news
There’s no doubt that kids need more sleep than adults. Their growing bodies and brains burn through a lot of energy, and adequate rest and recovery are essential for proper development. That’s why the National Sleep Foundation recommends that teens get eight to ten hours of sleep a night, while younger kids require more. But what about adults? It’s common for people to sleep fewer hours in middle age than during their 20s or 30s—and to report feeling fine. But does a person’s sleep requirements diminish with age? “No,” says Dr. Leila Kheirandish-Gozal, director of clinical sleep r...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime sleep Source Type: news
62.5 million more people could become eligible for drug treatment Related items fromOnMedica Blood pressure measurement Blood pressure below treatable threshold linked to heightened dementia risk High blood pressure before pregnancy linked to heightened miscarriage risk Genes isolated for pulmonary arterial hypertension Job strain linked to heightened risk of early death in men with heart disease/diabetes
Source: OnMedica Latest News - Category: UK Health Source Type: news
Publication date: Available online 21 June 2018Source: Molecular MetabolismAuthor(s): Andrea L. Hevener, Zhenqi Zhou, Timothy M. Moore, Brian G. Drew, Vicent RibasAbstractBackgroundThe incidence of chronic disease is elevated in women after menopause. Natural variation in muscle expression of the estrogen receptor (ER)α is inversely associated with plasma insulin and adiposity. Moreover, reduced muscle ERα expression levels are observed in women and animals presenting clinical features of the metabolic syndrome (MetSyn). Considering that metabolic dysfunction impacts nearly a quarter of the U.S. adult populatio...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 6 March 2018Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Shreyasi Asthana, Bibekanand Mallick, Andrei T. Alexandrescu, Suman JhaAbstractIslet amyloid polypeptide (a.k.a. IAPP, amylin) is a 37 amino acid hormone that has long been associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine peptide hormone aggregatively misfolds to form amyloid deposits in and around the pancreatic islet β-cells that synthesize both insulin and IAPP, leading to a decrease in β-cell mass in patients with the disease. Extracellular IAPP amyloid...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research
ConclusionsQuitting smoke in patients with DM2 is accompanied by a significant decrease in the estimated risk of coronary events as assessed by UKPDS. Our findings support the importance of quitting smoking among diabetic patients in order to reduce cardiovascular risk.ResumenObjetivosEvaluar el riesgo cardiovascular con la herramienta UKPDS risk engine, la función y escala Framingham y comparar las características clínicas de pacientes con diabetes mellitus tipo 2 (DM2) en base a sus hábitos.Pacientes y métodosSe llevó a cabo un análisis descriptivo. Se incluyó a un ...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Forrest H. NielsenAlthough official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary Mg ...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: June 2018Source: The Lancet Global Health, Volume 6, Issue 6Author(s): Ben Lacey, Sarah Lewington, Robert Clarke, Xiang Ling Kong, Yiping Chen, Yu Guo, Ling Yang, Derrick Bennett, Fiona Bragg, Zheng Bian, Shaojie Wang, Hua Zhang, Junshi Chen, Robin G Walters, Rory Collins, Richard Peto, Liming Li, Zhengming Chen, Junshi Chen, Zhengming ChenSummaryBackgroundThe age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, and before the widespread use of brain imaging for diagnosis of the main stroke types (ischaemic stroke and intracerebral haemorrh...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
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