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FDA warns of potential contamination in multiple brands of drugs, dietary supplements

The U.S. Food and Drug Administration is advising consumers and health care professionals not to use any liquid drug or dietary supplement products manufactured by PharmaTech LLC of Davie, Florida, and labeled by Rugby Laboratories, Major Pharmaceuticals and Leader Brands, due to potential contamination with the bacteria Burkholderia cepacia (B. cepacia) and the risk for severe patient infection.
Source: Food and Drug Administration - Category: American Health Source Type: news

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Lab tests have found Burkholderia cepacia contamination in PharmaTech's oral liquid docusate products, which has been linked to recent patient infections.News Alerts
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Alert Source Type: news
Rugby ® Laboratories of Livonia, MI is voluntarily recalling all lots within the expiry of Diocto Liquid and Diocto Syrup, (docusate sodium solutions) manufactured by PharmaTech, LLC of Davie, FL due to a risk of product contamination with Burkholderia cepacia. If a product contains B. cepacia, its use c ould result in infections in patients with compromised immune systems and in patients with chronic lung conditions such as cystic fibrosis. Some of these infections may be serious or even life-threatening in the at-risk patient population.
Source: Food and Drug Administration - Category: Food Science Source Type: news
Abstract Eggshell membrane (ESM) is an industrial waste that is available in abundance from food industry. Present study investigated the physicochemical properties of oxidized ESM and compared the efficiency of ESM and oxidized ESM as carrier for Burkholderia cepacia lipase (BCL) used in esters hydrolysis and transesterification. Following oxidation treatment, FTIR analysis and Ellman's assay showed amino acid cysteine in ESM was oxidized to form disulfide bond-containing cystine. In addition, AFM analysis showed ESM which exhibited a highly porous filamentous structure appeared to be coalesce following oxidation...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
This study aimed to screen the toxicity using the brine shrimp lethality assay and to investigate the inhibitory activity of carboxymethyl in isolation or in combination with silver nitrate, copper sulfate and zinc sulfate on biofilm formation by Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Kocuria rhizophila ATCC 9341, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 25312, and Burkholderia cepacia ATCC 17759. The CMCh was obtained by reacting chitosan with monochloroacetic acid under alkaline conditions, and the occurrence of carboxymethylation was evidenced by FTIR and (1)H NMR spectros...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Burkholderia cepacia complex is a group of opportunistic pathogens in cystic fibrosis (CF) patients believed to be associated with poor prognosis and patient-to-patient transmissibilit...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Source Type: research
1. Fifty-four bacteraemic Burkholderia cepacia complex (BCC) isolates were identified to the species level by the Bruker Biotyper MALDI-TOF MS system and 16S rRNA and recA genes sequencing analysis.2. Bruker Biotyper MALDI-TOF MS displays better performances to discriminate BCC species than 16S RNA sequencing analysis (79.6% vs. 16.7%).3. Higher rates of ceftazidime and meropenem resistance were found in B. cepacia isolates than B. cenocepacia and other species.4. Bacteraemia caused by BCC species other than B.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
Conclusion: This study highlights the importance of identification and molecular characterization of Bcc to establish its role in infection and outbreak.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Malavalli Venkatesh Bhavana, Sangeeta Joshi, Ranjeeta Adhikary, Hosdurg Bhaskar BeenaIndian Journal of Medical Microbiology 2017 35(2):318-319
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Abstract We tested the activity of ceftolozane-tazobactam and 13 other antimicrobial agents against 221 strains of Burkholderia cepacia complex and Burkholderia gladioli. Most strains (82%) were cultured from persons with cystic fibrosis, and most (85%) were recovered since 2011. The ceftolozane-tazobactam MIC was ≤ 8 μg/ml for 77% of the strains. However, the MIC range was broad (≤0.5 to>64 μg/ml; MIC50/90, 2/32 μg/ml). Significant differences in susceptibility to some antimicrobial agents were observed between species. PMID: 28674053 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Biofilms are a collective mode of bacterial life in which a self-produced matrix confines cells in close proximity to each other. Biofilms confer many advantages, including protection from chemicals (including antibiotics), entrapment of useful extracellular enzymes and nutrients, as well as opportunities for efficient recycling of molecules from dead cells. Biofilm matrices are aqueous gel-like structures composed of polysaccharides, proteins, and DNA stabilized by intermolecular interactions that may include non-polar connections. Recently, polysaccharides extracted from biofilms produced by species of the Burkholderia c...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Microbiology Source Type: research
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