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FDA warns of potential contamination in multiple brands of drugs, dietary supplements

The U.S. Food and Drug Administration is advising consumers and health care professionals not to use any liquid drug or dietary supplement products manufactured by PharmaTech LLC of Davie, Florida, and labeled by Rugby Laboratories, Major Pharmaceuticals and Leader Brands, due to potential contamination with the bacteria Burkholderia cepacia (B. cepacia) and the risk for severe patient infection.
Source: Food and Drug Administration - Category: American Health Source Type: news

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Green Chem., 2017, Advance Article DOI: 10.1039/C7GC02319G, PaperT. Nishihara, A. Shiomi, S. Kadotani, T. Nokami, T. Itoh Three types of triazolium cetyl-PEG10 sulfate ionic liquid were synthesized and their activation ofBurkholderia cepacia lipase was investigated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Chlorhexidine gluconate (CHX) and benzalkonium chloride (BZK) formulations are frequently used as antiseptics in healthcare and consumer products. Burkholderia cepacia complex (BCC) contamination of pharmaceutical products could be due to the use of contaminated water in the manufacturing process, over-diluted antiseptic solutions in the product, and the use of outdated products, which in turn, reduces the antimicrobial activity of CHX and BZK. To establish a "safe use" period following opening containers of CHX and BZK, we measured the antimicrobial effects of CHX (2 ~ 10 µg/ml) and BZK (...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research
Green Chem., 2017, Accepted Manuscript DOI: 10.1039/C7GC02319G, PaperTakashi Nishihara, Ayaka Shiomi, Shiho Kadotani, Toshiki Nokami, Toshiyuki Itoh Three types of triazolium cetyl-PEG10 sulfate ionic liquids were synthesized and their property for activation of Burkholderia cepacia lipase investigated; both the reaction rate and enantioselectivity depended on the cationic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: 20 November 2017 Source:Journal of Biotechnology, Volume 262 Author(s): Ashwini C. Mathpati, Vijyesh K. Vyas, Bhalchandra M. Bhanage Kinetic resolution of rac-1,2-diols using the biocatalyst Burkholderia cepacia lipase (BCL) immobilized on a biodegradable binary blend support of hydroxypropyl methyl cellulose(HPMC)/polyvinyl alcohol (PVA) has been investigated. The immobilization technique improved enzyme activity significantly and it has excellent recyclability with good yield and enantiomeric excess values up to the studied range of nine cycles. At optimum reaction conditions, conversion of 45–50...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
AbstractTheBurkholderia cepacia complex (BCC) can cause a severe decline in lung function in cystic fibrosis (CF). Our objective was to determine the BCC prevalence and to evaluate its clinical impact on CF. Clinical and laboratory variables were determined for CF patients with BCC (Group-A  = 50 patients) and without BCC (Group-B = 134 patients). The microorganisms were identified by biochemical tests, the Vitek2®Compact test,recA-PCR andrecA-nested-PCR with species-specific primers and DNA sequencing. The patients were evaluated by the Shwachman –Kulczycki score (SKCS), Bhalla score (BS), sp...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
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Source: Biotechnology and Bioengineering - Category: Biomedical Science Authors: Tags: Review Source Type: research
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01823A, PaperKazunori Yoshida, Masakazu Ono, Takahiro Yamamoto, Takashi Utsumi, Satoshi Koikeda, Tadashi Ema Industrial enzymes called lipase PS (LPS) and lipase AK (LAK), which originate fromBurkholderia cepacia andPseudomonas fluorescens, respectively, are synthetically useful biocatalysts. To strengthen their catalytic performances, we introduced... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Conclusions The pseudobacteraemia cases were caused by contaminated 0.5% CHG from a single company. Stricter government regulation is needed to prevent contamination of disinfectants during manufacturing. In addition, microbial contamination of antiseptics and disinfectants should be suspected when a B. cepacia outbreak occurs in hospitalised patients.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Conclusions Ongoing surveillance and prompt investigation of unusual disease outbreaks are vital for identifying sources of contamination of B. cepacia and protecting at-risk patients. Sound epidemiological methods are very important for identifying the source of any hospital infection outbreak.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Microbial Drug Resistance , Vol. 0, No. 0.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
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