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Britain is facing health 'time bomb' as obese children are hit by Type 2 Diabetes

THE nation is facing a public health “time bomb” as children as young as five fall victim to Type 2 Diabetes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Tighter rules on vending in NHS hope to tackle obesity amongst staff and patients Related items fromOnMedica ‘Upselling’ food/drink is fuelling the obesity crisis Childhood obesity plan to focus on calorie reduction Children obesity 'Disturbing' type 2 diabetes rise in children
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractWe aimed to corroborate glycemic control after bariatric surgery (BS) using continuous glucose monitoring (CGM) and analyze if data could predict long-term outcome. We evaluated 24 of our patients with type 2 diabetes who underwent BS (12 Roux-en-Y gastric bypass, RYGB, and 12 single-anastomosis duodeno-ileal bypass with sleeve gastrectomy, SADI-S) and who were in remission after 18 –24 months’ follow-up. At this time, a CGM device was placed for 7 days. Patients were reevaluated thereafter for at least 5 years. Glucose variability (GV) was lower in patients after SADI-S and in the 18 pat...
Source: Obesity Surgery - Category: Surgery Source Type: research
This study aimed to provide a comprehensive characterisation of LOX in human AT.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity).
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Abstract Chronic kidney disease (CKD) affects a substantial minority of persons with type 2 diabetes. Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed stage 3 or worse disease (estimated glomerular filtration rate (eGFR)
Source: Journal of Diabetes - Category: Endocrinology Authors: Tags: Editorial Source Type: research
Conclusions Total and vegetable calcium may be inversely associated with T2D incidence among women, regardless of impaired fasting blood glucose group or normal group. The associations may be potentially dose-responsive. Moderate dietary calcium may be related to lower risk of T2D incidence comparing to low intake group among women.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Conclusions/interpretation Overlapping genetic aspects should be considered and the presence of risk alleles of different genes together could contribute to the risk of T2D or obesity or both. The MTHFD1 and EXT2rs3740878 gene variants significantly affect obesity and not shared with T2D. Gene variants that showed combined effect on both disease entities were GCKR and PTGS1. These findings provide a basis for future studies on a larger scale. More stress on the risk gene variants that have a combined impact on both diabetes and obesity is recommended to improve risk prediction and preventive strategies.
Source: Egyptian Journal of Medical Human Genetics - Category: Genetics & Stem Cells Source Type: research
A recent study of human life expectancy uses a novel approach but the results offer no real surprises, confirming most of the current consensus associations. As a tour of the high level points, it is worth skimming. There are few genetic relationships that are large enough to be seen, and those that are visible are small in comparison to the impact of lifestyle choices. Excess fat tissue is just about as harmful as smoking for the obese: two months of life expectancy lost for every kilogram of excess weight. This all confirms the long-standing common wisdom when it comes to maintaining health for the long term - but also s...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Merton K, Davies MJ, Vijapurkar U, Inman D, Meininger G Abstract OBJECTIVE: In addition to achieving glycemic control, weight loss and blood pressure (BP) reduction are important components of type 2 diabetes mellitus (T2DM) management, as many patients with T2DM are overweight/obese and/or have hypertension. Canagliflozin, an SGLT2 inhibitor, has demonstrated improvements in HbA1c, body weight (BW), and systolic BP across a broad range of patients with T2DM. This analysis evaluated achievement of composite endpoints of HbA1c, BW, and systolic BP targets with canagliflozin versus placebo. METHODS: This...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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