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Britain is facing health 'time bomb' as obese children are hit by Type 2 Diabetes

THE nation is facing a public health “time bomb” as children as young as five fall victim to Type 2 Diabetes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Macrophages are critical for the initiation and resolution of the inflammatory phase of wound repair. In diabetes, macrophages display a prolonged inflammatory phenotype in late wound healing. Mixed-lineage leukemia-1 (MLL1) has been shown to direct gene expression by regulating nuclear factor-B (NF-B)–mediated inflammatory gene transcription. Thus, we hypothesized that MLL1 influences macrophage-mediated inflammation in wound repair. We used a myeloid-specific Mll1 knockout (Mll1f/fLyz2Cre+) to determine the function of MLL1 in wound healing. Mll1f/fLyz2Cre+ mice display delayed wound healing and decreased wound mac...
Source: Diabetes - Category: Endocrinology Authors: Tags: Immunology Immunology and Transplantation Source Type: research
CONCLUSIONS The high rates of DPN among youth with diabetes are a cause of concern and suggest a need for early screening and better risk factor management. Interventions in youth that address poor glycemic control and dyslipidemia may prevent or delay debilitating neuropathic complications.
Source: Diabetes Care - Category: Endocrinology Authors: Tags: Complications-Neuropathy Pathophysiology/Complications Source Type: research
In conclusion, exendin-4 activates the sirtuin pathway and increases energy expenditure in human adipocytes. Our results suggest another mechanism that may be responsible for body weight reduction observed in patients using GLP-1RAs. PMID: 28822994 [PubMed - as supplied by publisher]
Source: Acta Biochim Pol - Category: Biochemistry Authors: Tags: Acta Biochim Pol Source Type: research
AbstractPurposeAims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population.MethodsNinety patients affected by obesity (N = 39), type 2 diabetes mellitus (N = 26) or both (N = 25) were recruited. They were asked to maintain their usual physical activity habits during two consecutive weeks and to fill the questionnaires twice (at the end of each week). They were also asked...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Both green tea and metformin are used as adjuvants to treat and prevent complications associated with obesity; however, studies comparing their action and interaction in non-diabetic overweight women have not been reported. Thus, the current study evaluated the effects of green tea extract and metformin, both individually and in combination, on type 2 diabetes risk factors in non-diabetic overweight women.
Source: Clinical Nutrition ESPEN - Category: Nutrition Authors: Tags: Randomized Controlled Trial Source Type: research
Conclusions Taken together, the data show that lncRNAs are modulated in a model of obesity-associated type 2 diabetes and that variations in the expression of some of them may contribute to β-cell failure during the development of the disease.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Abstract BACKGROUND: As association of metabolic syndrome (MS) with chronic kidney disease (CKD) has not been extensively studied in patients with type 2 diabetes, we addressed these issues. METHODS: Intrapersonal means of 12 measurements of waist circumference, blood pressure and high-density lipoprotein (HDL) cholesterol and those of six measurements of fasting triglycerides during 12 months were calculated in a cohort of 168 previously reported Japanese patients with type 2 diabetes. Based on these means, MS was diagnosed according to the modified National Cholesterol Education Program Adult Treatment Pane...
Source: Clin Med Res - Category: Research Authors: Tags: J Clin Med Res Source Type: research
Xuan Gao, Carlos Salomon, Dilys J. Freeman
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsThere is widespread variation in access to surgery and in baseline patient characteristics in the countries submitting data to the IFSO Global Registry.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsLSG achieved significant weight loss and improvement of cardiometabolic risk factors among adolescents. However, the slight worsening of preexisting nutritional deficiencies warrants careful preoperative surveillance and appropriate postoperative nutritional supplementation.
Source: Obesity Surgery - Category: Surgery Source Type: research
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