Britain is facing health 'time bomb' as obese children are hit by Type 2 Diabetes
THE nation is facing a public health “time bomb” as children as young as five fall victim to Type 2 Diabetes.
Conditions: Obesity; Diabetes Mellitus, Type 2 Interventions: Drug: JNJ-64565111 Dose Level 1; Drug: JNJ-64565111 Dose Level 2; Drug: JNJ-64565111 Dose Level 3; Drug: Placebo Sponsor: Janssen Research & Development, LLC Recruiting
Obesity is a multifaceted, chronic, low-grade inflammation disease characterized by excess accumulation of dysfunctional adipose tissue. It is often associated with the development of cardiovascular (CV) disorders, insulin resistance and diabetes. Under pathological conditions like in obesity, adipose tissue secretes bioactive molecules called ‘adipokines’, including cytokines, hormones and reactive oxygen species (ROS). There is evidence suggesting that oxidative stress, in particular, the ROS imbalance in adipose tissue, may be the mechanistic link between obesity and its associated CV and metabolic complicat...
ConclusionsBoth obese and non-obese people with T2DM had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c.
This study was done, due to a continuous increase in the risk of obesity and type 2 diabetes in north Indian population, because of lifestyle and genetic variations. Clinically diagnosed subjects of type 2 diabetes mellitus (as per ADA criteria) were taken as cases and age and sex matched subjects without any associated illness were taken as controls. Obesity was estimated by calculating waist circumference and BMI in the study cases and controls. For genetic variation, DNA was isolated with Quaigen kit method and isolated DNA was amplified with PCR. Amplified DNA was resolved in 1% agarose gel electrophoresis. The Hardy &...
Conclusion: The significant correlations between PAI-1 levels and lipoprotein subfractions indicate the link between PAI-1 and lipid metabolism in obesity. PMID: 30002679 [PubMed]
Over the past few years a number of papers have tried to decipher the hormonal mechanisms which may promote weight loss following bariatric surgery in parallel or in conjunction witth pure restrictive aspects of any modern bariatric procedure. A particular attention was drawn on type 2 diabetes as, since a publication by Walter Pories , there was an improvement in glucose metabolism which preceeded by far the magnitude of weight loss following gastric bypass surgery. Several recent reviews [2-4] have discussed the role of the various gut hormones in bariatric and metabolic surgery but the present study by Jingge Yang re...
Schizophrenia associates with metabolic alterations and increased risk of cardiovascular diseases (CVDs), obesity, metabolic syndrome (MetS), type 2 diabetes, various cancers, and overall mortality (Vancampfort et al., 2013). Possibly due to unhealthy life-style and antipsychotics side-effects (Mitchell et al., 2013), patients with schizophrenia have an increased weight or comorbid obesity in 40-60%. Metabolic alteration are detectable at the earliest stages of illness, and their incidence increases in multi-episode patients (Minichino et al., 2017).
New research published in theNew England Journal of Medicinereports that weight loss before puberty in overweight children may reduce their risk of developing type-2 diabetes as adults.Medical Xpress
Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes, Published online: 13 July 2018; doi:10.1038/s41366-018-0148-4Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes
Conditions: Type 2 Diabetes Mellitus; Obesity; Nephropathy; Adolescent Obesity Interventions: Drug: Aminohippurate Sodium Inj 20%; Drug: Iohexol Inj 300 MG/ML Sponsor: University of Colorado Denver School of Medicine Barbara Davis Center Not yet recruiting