Testicular macrophages are guardians of fertility

(CNRS) The origin, development, and characteristics of two types of testicular macrophage have been described by a CNRS team at the Centre d'Immunologie de Marseille-Luminy. To elucidate the nature of these immune cells, the researchers used a novel cell tracing method. Their findings were published on Aug. 7, 2017, in the Journal of Experimental Medicine, and are of fundamental importance. They may help understand certain kinds of infertility in men and find new treatments for them.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Condition:   Infertility Intervention:   Other: pH Effect on blastocyst formation Sponsors:   Ibn Sina Hospital;   Banoon IVF Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Interstitial 5q22 deletions are relatively rare and usually represented by severe clinical features such as developmental delay and growth retardation. Here, we report a 23-year-old male patient, referred to our laboratory for genetic confirmation of possible familial adenomatous polyposis. MLPA and the subsequent array CGH identified an approximately 8-Mb-sized deletion in the 5q22.2q23.1 locus. Further analysis of the deleted region and the genes within suggested a possible role for theTSSK1B (testis-specific serine/threonine kinase 1) gene in the patient's reproductive capacity. Semen analysis confirmed that the patient...
Source: Molecular Syndromology - Category: Molecular Biology Source Type: research
AbstractPurposeThe aim of this study is to examine the impact of female body mass index (BMI) on IVF cycle outcomes.MethodsThis is a retrospective cohort study including 51,198 women who initiated their first autologous IVF cycle in 13 fertility centers in the USA between 2009 and 2015. The effect of underweight, overweight, and obese BMI on four different IVF cycle outcomes (cycle cancellation, oocyte and embryo counts, and ongoing clinical pregnancy [OCP]) was evaluated in logistic or Poisson regression analyses with confounders adjusted.ResultsWomen with an overweight or obese BMI experienced worse outcomes than those w...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionsThe sealtered sperm proteins and the increased spontaneous acrosome reaction rate might account for this unexplained male infertility in the R-ICSI pregnancy patients. The present proteomic results will throw light on the better understanding of the unexplained infertile mechanisms underlying these normozoospermic man who achieved R-ICSI pregnancy after IVF failure.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
Source: Human Fertility - Category: Reproduction Medicine Authors: Source Type: research
Caroline Bailey developed a rare bacterial infection and had to have her reproductive organs removed at the tender age of 11. But the 46-year-old from Missouri went on to adopt three children.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conditions:   Abnormal Uterine Bleeding;   Chronic Pelvic Pain;   Infertility, Female Intervention:   Drug: Misoprostol 200 mcg 2 Tab Sponsor:   Rajavithi Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Infertility Intervention:   Diagnostic Test: 16S rRNA gene sequencing Sponsor:   Reproductive Medicine Associates of New Jersey Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Our data show that oocyte cytoplasmic abnormalities significantly reduce fertilization achievement in poor responders. PMID: 30119150 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Andrologia, EarlyView.
Source: Andrologia - Category: Urology & Nephrology Authors: Source Type: research
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