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Testicular macrophages are guardians of fertility

(CNRS) The origin, development, and characteristics of two types of testicular macrophage have been described by a CNRS team at the Centre d'Immunologie de Marseille-Luminy. To elucidate the nature of these immune cells, the researchers used a novel cell tracing method. Their findings were published on Aug. 7, 2017, in the Journal of Experimental Medicine, and are of fundamental importance. They may help understand certain kinds of infertility in men and find new treatments for them.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
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Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
In this issue, Huang et  al. (1) provide their experience treating 8,583 couples with unexplained infertility using what has now become a standard approach using up with 3 cycles of ovarian-stimulation and intrauterine insemination (OS-IUI). They found that IUI live birth rates were significantly higher with stimulated cy cles using clomiphene citrate (50–100 mg), letrozole (2.5–5.0 mg), or gonadotropins (75 IU) compared with natural cycles for couples with unexplained or mild male-factor infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Publication date: Available online 17 April 2018 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Seema Patel Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
(Goethe University Frankfurt) One of the most significant impairments of the quality of life after a chemotherapy is infertility. Researchers of the Goethe University and the University Tor Vergata in Rome have now identified the mechanism of chemotherapy-induced infertility in females.
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