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Nurse-led screening in GP practices boosts early lung cancer and COPD detection

A nurse-led screening programme in Liverpool is preventing around two cases of lung cancer a month across a dozen practices and driving up early detection of COPD, researchers have found.
Source: GP Online News - Category: Primary Care Tags: 15.8 Respiratory Problems Source Type: news

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CONCLUSIONS: A large proportion of workers performing common tasks in the construction industry may be exposed to levels of respirable dust and crystalline silica exceeding national standards and international recommendations. These results suggest that workers in this industry may be at risk of developing silica-related diseases, including silicosis, lung cancer, COPD and chronic renal disease. Action is required to improve dust control to reduce silica exposure and the associated health risks. PMID: 29197904 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Background: COPD patients have an increased risk of development of lung cancer, but its underlying mechanisms are poorly understood. We aimed to identify risk factors for lung cancer in patients from the Bergen COPD Cohort Study.Methods: We compared 433 COPD patients with 279 healthy controls, all former or current smokers. All COPD patients had a FEV1
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Rationale: Patients with severe COPD and/or emphysema have a distinct pulmonary inflammome characterized by a different regulation of the immune response that should be better explored integrating the results of RNA expression with epigenetic changes.Objective: To compare the pulmonary mRNA and miRNA of COPD patients with and without emphysema (CT scan) and various disease severity.Methods: Lung tissue from 70 former smokers with COPD was obtained from individuals undergoing thoracic resectional surgery (mostly because of lung cancer) or lung transplantation explants. Total RNA was extracted, small RNA libraries were const...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
Conclusion: The prevalence of COPD in Sri Lankan adults is similar to global and regional prevalences.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Introduction: In the era of personalised medicine post-genomic biomarkers could be employed to evaluate respiratory diseases. Particularly important targets are the rapid diagnosis, typing and staging of lung cancer (LC) and predicting exacerbations in patients with chronic obstructive pulmonary disease (COPD) which often occur as co-morbidities. In such approaches screens based on sputum, represent an attractive prospect.Materials and Methods: Spontaneous sputum was collected from 155 patients and correlated with the corresponding clinic-radiological diagnosis (COPD, LC, controls derived from heavy smokers). Global DNA ex...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
Background: The association betweem alpha-1 antitrypsin (AAT) and lung cancer remains unclear. We investigated AAT serum levels in PiMM non-small cell lung cancer (NSCLC) patients with respect to PiMM controls with COPD and benign lung nodules since AAT is an acute-phase protein. PiMM is the most common normal phenotype associated with 100% serum level of AAT, so our measurements of AAT serum concentration were not biased by the diversity of AAT variants. The AAT tumor tissue expression was analyzed in NSCLC group to evaluate the potential contribution of cancer cells to AAT production.Methods: Serum and matched FFPE tissu...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion: Bronchopulmonary system effects under combined action of external exposure and inhalation of radionuclides at the ChNPP accident realized in radiationinduced pathomorphosys of pulmopathology (ChB, COPD and Lung Cancer).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and Environmental Health Source Type: research
Conclusions: Severe airflow limitation represents a distinctive transcriptomic signature in comparison to mild COPD and non-smokers. Transcriptomic changes of mild former smokers with COPD vs. non-smokers are more heterogeneous.Supported, in part, Instituto de Salud Carlos III (PI15/00799), CP (16/00039) and a grant from MSD.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
In conclusion, NGS analysis revealed a partially different molecular profile with a higher number of mutations in lung adenocarcinoma of smokers without COPD compared to those with COPD. These results should be confirmed by larger scale studies to understand their translational value.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
COPD, characterized by chronic bronchitis, small airway remodeling and emphysema, is one of the leading causes of chronic morbidity and mortality worldwide. Chronic lung injury, commonly caused by cigarette smoking (CS), is a major factor in its development. A role for epigenetics in this underlying pathology is emerging. We previously detected spontaneous emphysema in HMGN5-/-mice. HMGN5 binds to the nucleosomal core particle of chromatin, competing with histone H1, altering chromatin structure and affecting cellular transcription, differentiation and repair. Indeed, increased expression of HMGN5 has been observed in lung...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
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