Nurse-led screening in GP practices boosts early lung cancer and COPD detection

A nurse-led screening programme in Liverpool is preventing around two cases of lung cancer a month across a dozen practices and driving up early detection of COPD, researchers have found.
Source: GP Online News - Category: Primary Care Tags: 15.8 Respiratory Problems Source Type: news

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(European Lung Foundation) The European Respiratory Society International Congress will take place at the Paris Expo Porte de Versailles from September 15 to 19, 2018.The Congress will be attended by the world's leading respiratory experts who will present cutting-edge research in a large and varied scientific program. Over 4,000 abstracts will cover a diverse range of disease areas and specialisms, including lung cancer, asthma and COPD, children's lung health, personalized medicine, e-cigarettes, AI and risk factors.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: There is an urgent need for further research that can help guide clinical decision-making with patients who may not benefit from LCS owing to coexisting chronic illness. This statement establishes a research framework to address essential questions regarding how to incorporate and communicate risks of comorbidities into patient selection and decisions regarding LCS. PMID: 30004250 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune response to smoke ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Publication date: August 2018Source: Regulatory Toxicology and Pharmacology, Volume 97Author(s): S. Djurdjevic, Z. Sponsiello-Wang, P.N. Lee, J.S. Fry, R. Weitkunat, F. Lüdicke, G. BakerAbstractReduced Risk Products (RRPs) do not burn tobacco and produce lower levels of toxicants than in cigarette smoke. The long-term effects of using RRPs on health are difficult to assess in a pre-market setting and a modeling approach is required to quantify harm reduction. The Population Health Impact Model (Weitkunat et al., 2015) follows a hypothetical population of individuals over time, creating their tobacco use histories and,...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
Annals of Human Genetics, EarlyView.
Source: Annals of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
ConclusionsThe use of the COPD-LUCSS-DLCO score in standard clinical practice could help detect patients with a greater risk of developing LC, which could help to better manage cases in an LC screening program.ResumenIntroducciónEl score COPD-LUCSS-DLCO ha sido validado como una herramienta predictiva capaz de identificar pacientes con enfermedad pulmonar obstructiva crónica (EPOC) y alto riesgo de fallecer por cáncer de pulmón (CP). No obstante, hasta la fecha no se han realizado estudios acerca de su uso en la práctica clínica habitual. El objetivo del estudio fue estimar las pun...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: July 2018Source: Pharmacology &Therapeutics, Volume 187Author(s): Philippe Lachapelle, Meina Li, Jo Douglass, Alastair StewartAbstractThe transforming growth factor (TGF)-β cytokines play a central role in development and progression of chronic respiratory diseases. TGF-β overexpression in chronic inflammation, remodeling, fibrotic process and susceptibility to viral infection is established in the most prevalent chronic respiratory diseases including asthma, COPD, lung cancer and idiopathic pulmonary fibrosis. Despite the overwhelming burden of respiratory diseases in the world, new pharmac...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: July 2018Source: Pharmacology &Therapeutics, Volume 187Author(s): Wioletta Skronska-Wasek, Reinoud Gosens, Melanie Königshoff, Hoeke Abele BaarsmaAbstractThe WNT signalling cascades have emerged as critical regulators of a wide variety of biological aspects involved in lung development as well as in physiological and pathophysiological processes in the adult lung. WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways that regulate transcriptional as well as non-transcriptional responses within cells. In physiological condition...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 4 May 2018Source: Pharmacology &TherapeuticsAuthor(s): T. Sécher, L. Guilleminault, K. Reckamp, I. Amanam, L. Plantier, N. Heuzé-Vourc'hAbstractRespiratory diseases affect millions of people worldwide, and account for significant levels of disability and mortality. The treatment of lung cancer and asthma with therapeutic antibodies (Abs) is a breakthrough that opens up new paradigms for the management of respiratory diseases. Antibodies are becoming increasingly important in respiratory medicine; dozens of Abs have received marketing approval, and many more are currently...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Authors: Jiang G, Liu CT, Zhang WD Abstract Smoking is one of the primary causes of chronic obstructive pulmonary disease (COPD). Sustained active epithelial-mesenchymal transition (EMT) in COPD may explain the core pathophysiology of airway fibrosis and why lung cancer is so common among smokers. Interleukin (IL)-17A and growth/differentiation factor (GDF)15 have been reported to be biomarkers of COPD; however, the role of IL-17A and GDF15 in EMT remains unclear. The aim of the present study was to investigate the role of IL-17A and GDF15 in the pathogenesis of COPD. It was demonstrated that IL-17A and GDF15 are u...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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