Psychotic symptoms influence the development of anterior cingulate BOLD variability in 22q11.2 deletion syndrome

Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder associated with a broad phenotype of clinical, cognitive and psychiatric features. Due to the very high prevalence of schizophrenia (30 –40%), the investigation of psychotic symptoms in the syndrome is promising to reveal biomarkers for the development of psychosis, also in the general population. Since schizophrenia is seen as a disorder of the dynamic interactions between brain networks, we here investigated brain dynamics, asse ssed by the variability of blood oxygenation level dependent (BOLD) signals, in patients with psychotic symptoms.

Source: Schizophrenia Research - August 10, 2017 Category: Psychiatry Authors: Daniela Z öller, Maria Carmela Padula, Corrado Sandini, Maude Schneider, Elisa Scariati, Dimitri Van De Ville, Marie Schaer, Stephan Eliez Source Type: research