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Microbiota-activated PPAR-{gamma} signaling inhibits dysbiotic Enterobacteriaceae expansion

Perturbation of the gut-associated microbial community may underlie many human illnesses, but the mechanisms that maintain homeostasis are poorly understood. We found that the depletion of butyrate-producing microbes by antibiotic treatment reduced epithelial signaling through the intracellular butyrate sensor peroxisome proliferator–activated receptor (PPAR-). Nitrate levels increased in the colonic lumen because epithelial expression of Nos2, the gene encoding inducible nitric oxide synthase, was elevated in the absence of PPAR- signaling. Microbiota-induced PPAR- signaling also limits the luminal bioavailability of oxygen by driving the energy metabolism of colonic epithelial cells (colonocytes) toward β-oxidation. Therefore, microbiota-activated PPAR- signaling is a homeostatic pathway that prevents a dysbiotic expansion of potentially pathogenic Escherichia and Salmonella by reducing the bioavailability of respiratory electron acceptors to Enterobacteriaceae in the lumen of the colon.
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases, Microbiology r-articles Source Type: news

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Source: International Journal of Cosmetic Science - Category: Dermatology Authors: Tags: Original Article Source Type: research
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Source: Research in Microbiology - Category: Microbiology Source Type: research
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Source: Gut Pathogens - Category: Microbiology Source Type: research
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Source: Journal of General and Applied Microbiology - Category: Microbiology Tags: J Gen Appl Microbiol Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Journal of Medical Virology - Category: Virology Authors: Tags: Research Article Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Science Selection Source Type: research
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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics News Source Type: news
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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