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Numerate receives NIH funding to discover new anti-arrhythmic treatments

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) has awarded a small business innovation research (SBIR) Phase I grant to Numerate to boost a new drug programme for cardiac arrhythmias.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Conclusions— Genetic variation contributes substantially to AF risk. The risk for AF conferred by genomic variation is similar to that observed for several other cardiovascular diseases. Established AF loci only explain a moderate proportion of disease risk, suggesting that further genetic discovery, with an emphasis on common variation, is warranted to understand the causal genetic basis of AF.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Arrhythmias, Atrial Fibrillation, Epidemiology, Genetic, Association Studies, Genetics Original Articles Source Type: research
No abstract available
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Electrophysiology Source Type: research
Treatment of cardiac arrhythmias often involves ablating viable muscle tissue within or near islands of scarred myocardium. Yet, today there are limited means by which the boundaries of such scars can be visualized during surgery and distinguished from the sites of acute injury caused by radiofrequency (RF) ablation.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
There is mounting evidence that besides increasing risk of cirrhosis, end stage liver disease and hepatocellular carcinoma, non alcoholic fatty liver disease (NAFLD) also affects risk of disease in organs beyond the liver[1]. For example, NAFLD is an independent risk factor for cardiovascular disease[2], type 2 diabetes[3] and chronic kidney disease[4], and NAFLD also increases risk of cardiac arrhythmias and aortic valve disease [1]. However, whether NAFLD is a risk factor for impaired myocardial function is uncertain.In a study of 308 asymptomatic subjects recruited from attendees at a Health Promotion Centre in a Univer...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Premature ventricular contractions (PVCs) are very common cardiac arrhythmias, detected on up to 75  % of Holter monitors of ambulatory patients.1 Although PVCs in the setting of advanced structural heart disease have independent negative prognostic implications,2 the majority of PVCs are quite benign, associated with neither symptoms nor signals of future harm. For an important minority, PVCs represent an important medical condition that requires treatment.
Source: Radcliffe Cardiology - Category: Cardiology Authors: Source Type: research
Publication date: Available online 7 December 2017 Source:Canadian Journal of Cardiology Author(s): Jari M. Tuomi, Anargyros Xenocostas, Douglas L. Jones Atrial Fibrillation (AF) is a side-effect of ibrutinib, an irreversible inhibitor of Bruton’s tyrosine kinase used for treatment of B-cell lymphoproliferative disorders. We determined if single (2 or 10 mg/kg), or chronic (14 day) oral ibrutinib followed by 24 hour washout conferred susceptibility to electrically-induced arrhythmias in 1-mo male C57BL/6 mice. A single higher dose of ibrutinib increased arrhythmia inducibility. There was no inducibility difference a...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Conditions:   Arrhythmia;   Atrial Fibrillation;   Atrial Flutter;   Atrial Tachycardia;   Supraventricular Tachycardia;   Ventricular Ectopic Beat(S);   Cardiac Arrythmias Intervention:   Device: esoECG-3D catheter Sponsor:   University Hospital Inselspital, Berne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Purpose of review Atrial fibrillation is the most common sustained cardiac arrhythmia, attributable to several factors that may be amenable through lifestyle modification. There is emerging evidence to suggest that the successful management of several cardiovascular risk factors [obesity, hypertension (HTN), diabetes mellitus, and obstructive sleep apnea (OSA)] can lead to fewer complications and atrial fibrillation prevention. However, the long-term sustainability and reproducibility of these effects have yet to be explored in larger studies. This review explores recent findings for exercise and lifestyle modifications ...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: ARRHYTHMIAS: Edited by David Birnie Source Type: research
Authors: Papadopoulos CH, Oikonomidis D, Lazaris E, Nihoyiannopoulos P Abstract Cardiac arrhythmias refer to any abnormality or disturbance in the normal activation sequence of the myocardium and may be indicative of structural heart disease as well as the cause of significant cardiovascular complications and sudden cardiac death. The following review summarizes the current state-of-the-art knowledge on the role of echocardiography in the management of cardiac arrhythmias and focuses on atrial fibrillation and ventricular arrhythmias where echocardiography presents a particular diagnostic and prognostic interest. M...
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
CONCLUSIONS: In patients with CS complicating AMI, the presence of CTO in a non-IRA is associated with a higher incidence of ventricular arrhythmias and is an independent predictor of mortality at 12-month follow-up. PMID: 29205158 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
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