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Numerate receives NIH funding to discover new anti-arrhythmic treatments

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) has awarded a small business innovation research (SBIR) Phase I grant to Numerate to boost a new drug programme for cardiac arrhythmias.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Conclusions and Clinical ImportanceThe prognosis for resolution of clinical signs after air embolism is fair, but permanent neurologic deficits or pathologic cardiac arrhythmias can arise. Unpredictable progression warrants close monitoring. Systematic clinic‐based surveillance could provide additional useful information to aid prevention.
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: STANDARD ARTICLE Source Type: research
Authors: Trappe HJ Abstract The 12-lead surface electrocardiogram (ECG) is of great importance for the diagnostics of cardiac arrhythmias. For the correct and systematic analysis it has a sensitivity and specificity for the correct diagnosis of supraventricular tachycardia or ventricular tachycardia of more than 95%. Nevertheless, the assessment of cardiac rhythm disorders is difficult for many physicians. In this way errors can occur, frequently due to a non-systematic analysis of the ECG; therefore, the aim of this article is to present the techniques and the necessary knowledge for assessment of the most frequen...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults, associated with significant morbidity, increased mortality, and rising healthcare costs. Simple and available tools for the accurate detection of arrhythmia recurrence in patients after electrical cardioversion or ablation procedures for AF can help to guide therapeutic decisions. We conducted a prospective, single-center study to evaluate the accuracy of Cardiio Rhythm Mobile Application (CRMA) for AF detection.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
In this paper, we report the autopsy findings of a 42-year-old White male who was found deceased at his home by his brother in the early morning hours with a history of excessive alcohol consumption 1 day before his death. A medical record review revealed chronic alcohol use with alcohol dependence syndrome, hypertension, and cardiac arrhythmias by electrocardiogram 2 years prior. External examination revealed only a single bruise on the forehead. Internal examination revealed changes associated with chronic alcohol abuse and mild atherosclerosis. The lack of a cause of death at autopsy resulted in a dissection of the card...
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Case Reports Source Type: research
ConclusionWe successfully demonstrated the feasibility of the proposed ROMANCE MRA in generating robust angiograms with background suppression.
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Full Paper Source Type: research
CONCLUSION: We successfully demonstrated the feasibility of the proposed ROMANCE MRA in generating robust angiograms with background suppression. PMID: 29427402 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Magn Reson Med Source Type: research
Total knee arthroplasty (TKA) often causes a significant amount of blood loss with an accompanying decline in hemoglobin and may increase the frequency of allogeneic blood transfusion rates. Unfortunately, allogeneic blood transfusions have associated risks including postoperative confusion, infection, cardiac arrhythmia, fluid overload, increased length of hospital stay, and increased mortality. Other than reducing the need for blood transfusions, reducing perioperative blood loss in TKA may also minimize intra‐articular hemorrhage, limb swelling, and postoperative pain, and increase the range of motion during the early...
Source: Orthopaedic Surgery - Category: Orthopaedics Authors: Tags: REVIEW ARTICLE Source Type: research
Conclusions: At baseline Ca2+-dependent upregulation of IKr and IKs in HF counterbalances the reduced IK1, maintaining repolarization reserve (especially at higher heart rates) in physiological conditions, unlike conditions of strong cytosolic Ca2+ buffering. However, under β-adrenergic stimulation, reduced IKs responsiveness severely limits integrated repolarizing K+ current and repolarization reserve in HF. This would increase arrhythmia propensity in HF, especially during adrenergic stress.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Electrophysiology, Ion Channels/Membrane Transport, Heart Failure Original Articles Source Type: research
The objective of this review was to summarize the efficacy of lifestyle interventions for the management of AF. Studies which included patients with systolic heart failure (ejection fraction ≤ 40%), and those limited to an examination of vigorous physical activity were excluded from our search.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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