Neuroprotective role of Agmatine in Neurological Diseases.

Neuroprotective role of Agmatine in Neurological Diseases.
Curr Neuropharmacol. 2017 Aug 08;:
Authors: Xu W, Gao L, Li T, Shao A, Zhang J
Abstract
Neurological diseases have always been one of the leading cause of mobility and mortality world-widely. However, it is still lack of efficient agents. Agmatine, an endogenous polyamine, exerts its diverse biological characteristics and therapeutic potential in varied aspects. Moreover, there has been numerous studies demonstrated the neuroprotective effect of agmatine in varied types of neurological diseases, including acute attack (stroke and trauma brain injury) and chronic neurodegenerative diseases (Parkinson's disease, Alzheimer's disease). The potential mechanism of agmatine -induced neuroprotection includes anti-oxidation, anti-apoptosis, anti-inflammation, brain blood barrier (BBB) protection and brain edema prevention. In this review, we will introduce the neuroprotective effects of agmatine and the underlying mechanisms in the setting of neurological diseases.
PMID: 28786346 [PubMed - as supplied by publisher]

Source: Current Neuropharmacology - August 8, 2017 Category: Drugs & Pharmacology Authors: Xu W, Gao L, Li T, Shao A, Zhang J Tags: Curr Neuropharmacol Source Type: research