Development of a balance, safe mobility and falls management programme for people with multiple sclerosis - Gunn H, Endacott R, Haas B, Marsden J, Freeman J.
PURPOSE: To utilise stakeholder input to inform the structure, format and approach of a multiple sclerosis (MS) balance, safe mobility and falls management programme. MATERIALS AND METHODS: Using a three-round nominal group technique, participants ...
Authors: Arnon R, Aharoni R Abstract BACKGROUND: Glatiramer acetate (GA, Copaxone®, Copolymer1, Cop 1) is an approved drug for the treatment of relapsing-remitting multiple sclerosis (RRMS). Its efficacy in reducing the frequency of exacerbations and its safety profile establish it as a first-line therapy for MS. Evidence from the animal model experimental autoimmune encephalomyelitis (EAE) and from MS patients indicate that GA affects various levels of the innate and the adaptive immune response, inducing deviation from the pro-inflammatory to the anti-inflammatory pathways. This includes mainly the induction ...
ConclusionThis is an example supporting the usefulness of NfL in monitoring disease activity pwMS which may predict disease activity prior to a clinical exacerbation.
Condition: Multiple Sclerosis Interventions: Device: Inspiratory muscle trainer; Procedure: Respiratory exercise Sponsor: University of Salamanca Not yet recruiting
Conditions: Multiple Sclerosis; Physical Therapy Interventions: Other: Vojta Therapy; Other: Standard Program Sponsors: NUMEN Foundation; Multiple Sclerosis Foundation of Madrid; Fisiovillalba Clinical center Recruiting
ConclusionOur findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis. This supports a model for RRMS in children with an apparent iron-deficient biochemical subtype of MS, with oligodendrocyte cell death and impaired myelination possibly caused by deficits of energy- and antioxidant capacity in mitochondria.
Publication date: Available online 22 March 2019Source: The Lancet NeurologyAuthor(s): Daniel Friedman, Jacqueline A French, Mauro MaccarroneSummaryIn the past two decades, there has been an increasing interest in the therapeutic potential of cannabinoids for neurological disorders such as epilepsy, multiple sclerosis, pain, and neurodegenerative diseases. Cannabis-based treatments for pain and spasticity in patients with multiple sclerosis have been approved in some countries. Randomised controlled trials of plant-derived cannabidiol for treatment of Lennox-Gastaut syndrome and Dravet syndrome, two severe childhood-onset ...
Publication date: Available online 23 March 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Livnat Brill, Iris Lavon, Adi Vaknin-Dembinsky
Conclusion: Our findings suggest that cyclophosphamide may be a therapeutic alternative to induce clinical and radiological improvement in Marburg Disease.
CONCLUSION: Comorbidity is highly prevalent in MS throughout the disease course. Comorbid conditions, including depression, anxiety, hypertension, hyperlipidemia, diabetes and chronic lung disease, adversely affect a broad range of outcomes. Less is known about the effects of MS on outcomes related to these comorbid conditions. These findings highlight an urgent need to determine how to best prevent and treat comorbidity in MS. PMID: 30904030 [PubMed - in process]
This study was conducted to determine the effect of life skills training on the self-management of patients with multiple sclerosis. Findings showed that life skills training had a significant effect on the overall self-management score; thus, self-management of patients increased after training life skills (F = 25.1821, P