High blood pressure - is THIS really the safest way of treating hypertension?
LOWERING blood pressure to a level less than what is considered to be a normal blood pressure could benefit patients. However, now experts have said this method could actually harm people rather than help them.
This study explored the oxidative stress effects of the NADPH oxidase-ROS-NF-κB transduction pathway and vascular peroxidase 1 (VPO1) on patients with chronic obstructive pulmonary disease (COPD) combined with pulmonary hypertension (PH). PATIENTS AND METHODS: 30 patients with pure COPD and 30 patients with stable COPD combined with PH, who were admitted to our hospital from January 2015 to December 2015, were enrolled as the control group and the observation group, respectively. NADPH oxidase activity in mononuclear cells, reactive oxygen species (ROS), NF-κB, VPO1 levels in serum, and further oxidative st...
Authors: Tachibana T, Nakayama N, Matsumura A, Nakajima Y, Takahashi H, Miyazaki T, Nakajima H Abstract A 65-year-old man was diagnosed with polycythemia vera (PV) and treated with hydroxyurea. Three years later, he was admitted to our institution for severe hypoxia. Right heart catheterization revealed that the patient had pulmonary hypertension (PH). In addition, radiographic findings and resistance to pulmonary vasodilators led to the diagnosis of PH associated with pulmonary veno-occlusive disease. The administration of ruxolitinib improved his hematopoiesis and respiratory failure. While the disease is relativ...
Conclusion We found that a Salt Check Sheet composed of the 5 items that showed a strong correlation with the salt intake might be more useful for periodic health checks of the working-age population. PMID: 28824058 [PubMed - as supplied by publisher]
Several modifiable aspects of patient-provider communication contribute to poor medication adherence in patients with hypertension, researchers report.Reuters Health Information
Study used NHANES data to look at the prevalence of hypertension in adults in Los Angeles County.
Conclusions: This study identified MEG3 as a critical regulator in PAH and demonstrated the potential of gene therapy and drug development for treating PAH.Cell Physiol Biochem 2017;42:2569 –2581
Doctors can help boost use of high blood pressure medications by their poor patients simply by talking to them, a new study suggests.
Melissa A. Lyle, Jonathan P. Davis, Frank V. Brozovich
Abstract Diuretics are commonly prescribed for treatment in patients with hypertension, edema, or heart failure. Studies on hypertensive and salt-losing disorders and on urea transporters have contributed to better understanding of mechanisms of renal salt and water reabsorption and their regulation. Proteins involved in the regulatory pathways are emerging targets for diuretic and aquaretic therapy. Integrative high-throughput screening, protein structure analysis, and chemical modification have identified promising agents for preclinical testing in animals. These include WNK-SPAK inhibitors, ClC-K channel antago...
Abstract Type 2 diabetes mellitus (T2DM) is a metabolic disease affecting an increasing percentage of general population worldwide. Patients with T2DM are frequently characterized by impaired renal function, primarily as a result of diabetic kidney injury, but also by other contributing factors, such as hypertension, atherosclerosis, and medications. Sodium-glucose cotransporter (SGLT)-2 inhibitors have emerged as a new, promising class of antidiabetic agents with actions that seem to extend beyond their hypoglycemic effect. PMID: 28480956 [PubMed - indexed for MEDLINE]