Sleep - Disordered Breathing Linked to Cognitive Dysfunction
Hypoxemia and sleepiness associated with cognitive deficits, with strongest effect in APOE - ε 4 carriers
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects...
Do you need 12 hours of sleep per day to function? Or is 2 hours per night enough for you? A new study investigates the genetics behind these differences.
Conclusions:Both adherence and nonadherence to CPAP are dynamic processes that are characterized by patients' ambivalence and contingent upon diverse factors. These findings have practical implications as they suggest that all patients, regardless of their initial adherence status, would benefit from a close follow-up.Citation:Zarhin D, Oksenberg A. Ambivalent adherence and nonadherence to continuous positive airway pressure devices: a qualitative study.J Clin Sleep Med. 2017;13(12):1375–1384.
Conclusions:The main cause of nonuse of CPAP in India is the inability to buy a CPAP device. In patients who are able to buy a CPAP device, adherence was significantly higher (82.7%) compared to adherence in the study's overall population (30.3%). Furthermore, patients with more severe OSA were more likely to buy a device and adhere to CPAP. Patients' behaviors and attitudes are also important barriers in using CPAP. There needs to be increased awareness of the benefits of CPAP therapy among patients.Citation:Goyal A, Agarwal N, Pakhare A. Barriers to CPAP use in India: an exploratory study.J Clin Sleep Med. 2017;13(12):1385–1394.
This study evaluated the association between the total testosterone (TT) level and OSA in patients who are not obese.Methods:A retrospective review of 523 records of patients in whom OSA was diagnosed from 2013–2016 was performed. The study included men with a BMI
Conclusions:Overall, sleep characteristics did not differ among noncaregivers, ceased caregivers, or those with high-/low-intensity caregiving among older women. However, subgroups of caregivers may be vulnerable to developing sleep problems, particularly those with high stress levels.Citation:Song Y, Harrison SL, Martin JL, Alessi CA, Ancoli-Israel S, Stone KL, Fredman L. Changes in caregiving status and intensity and sleep characteristics among high and low stressed older women.J Clin Sleep Med. 2017;13(12):1403–1410.
Conclusions:In systolic HF, although overall objective sleepiness was observed, this was not associated with subjective sleepiness (ie, a discordance was identified). Differential upregulation of systemic inflammation in objective sleepiness was observed, findings not observed with subjective sleepiness. These findings suggest that underlying mechanistic pathways of inflammation may provide the explanation for dissonance of objective and subjective sleepiness symptoms in HF, thus potentially informing targeted diagnostic and therapeutic approaches.Commentary:A commentary on this article appears in this issue on page 1369.C...
Conclusions:The results of this study showed that higher levels of CPAP adherence were associated with significant improvements in vigilance. Because the PVT is a performance-based measure that is not influenced by prior learning and is not subjective, it may be an important supplement to patient self-reported assessments.Clinical Trial Registration:Name: Effect of Self-Management on Improving Sleep Apnea Outcomes, URL:https://clinicaltrials.gov/ct2/show/NCT00310310, Identifier: NCT00310310Citation:Deering S, Liu L, Zamora T, Hamilton J, Stepnowsky C. CPAP adherence is associated with attentional improvements in a group of...