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Antibiotic ineffective at preventing lung complication after stem cell transplant: Study

An antibiotic treatment intended to lower stem cell transplant patients' risk of developing a respiratory complication appears to have backfired.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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This study didn't measure whether receiving the cardiosphere-derived cells extended lifespans, so we have a lot more work to do. We have much to study, including whether CDCs need to come from a young donor to have the same rejuvenating effects and whether the extracellular vesicles are able to reproduce all the rejuvenating effects we detect with CDCs." Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however,...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Title: Antibiotic Doesn't Prevent Lung Complication After Stem Cell TransplantCategory: Health NewsCreated: 8/8/2017 12:00:00 AMLast Editorial Review: 8/9/2017 12:00:00 AM
Source: MedicineNet Lungs General - Category: Respiratory Medicine Source Type: news
Findings were so dismal that clinical trial was stopped early
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Infections, Oncology, Pharmacy, Pulmonology, Research, News, Source Type: news
Findings were so dismal that clinical trial was stopped earlySource: HealthDay Related MedlinePlus Pages: Lung Cancer, Stem Cells
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
TUESDAY, Aug. 8, 2017 -- An antibiotic treatment intended to lower stem cell transplant patients'risk of developing a respiratory complication appears to have backfired. French researchers explored the potential of administering the antibiotic...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Findings were so dismal that clinical trial was stopped early
Source: Cancercompass News: Other Cancer - Category: Cancer & Oncology Source Type: news
This study determined the therapeutic effects of human mesenchymal stem cells (MSCs) on pulmonary hypertension in an animal model. Pregnant Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS, 0.5 mg/kg/day) on gestational days 20 and 21. The pups were randomly assigned to two treatment conditions: room air (RA) or an O2-enriched atmosphere. On postnatal day 5, they were intratracheally transplanted with human MSCs (3 × 105 and 1 × 106 cells) in 0.03 mL of normal saline (NS). Five study groups were examined: normal, LPS+RA+NS, LPS+O2+NS, LPS+O2+MSCs (3 × 105 cells), and LPS+O2...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In recent years the research community has made some progress towards the use of cell therapies to treat fibrosis in lung tissue, the basis for a number of ultimately fatal conditions that present cannot be effectively controlled. Fibrosis is a disruption of the structure of tissue, the formation of scar-like structures that degrade tissue function. This line of research may soon be overtaken by the use of senolytic treatments to remove senescent cells, given that senescent cells appear to be a significant cause of the age-related failures in regenerative processes that cause fibrosis. Nonetheless, prior to recent work on ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusion: These results suggest the potential use of ADHLSCs in the treatment of hemophilia A.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science-Liver Source Type: research
SummaryThe anti-inflammatory and antibacterial mechanisms of bone marrow mesenchymal stem cells (MSCs) ameliorating lung injury in chronic obstructive pulmonary disease (COPD) mice induced by cigarette smoke andHaemophilus Parainfluenza (HPi) were studied. The experiment was divided into four groupsin vivo: control group, COPD group, COPD+HPi group, and COPD+HPi+MSCs group. The indexes of emphysematous changes, inflammatory reaction and lung injury score, and antibacterial effects were evaluated in all groups. As compared with control group, emphysematous changes were significantly aggravated in COPD group, COPD+HPi group ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - Category: Research Source Type: research
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