Medical News Today: Could probiotics help to fight multiple sclerosis?

Multiple sclerosis, a debilitating autoimmune disease, is difficult to treat. New research looking at the role of gut bacteria offers new hope.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

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ConclusionAutoimmune epilepsy without obvious causative lesion on MRI can be seen in the course of anti-MOG antibody associated demyelinating disease. The subsequent emergence of tumefactive lesion closely located to the epileptic foci may suggest some association between autoimmune epilepsy and demyelinating lesions.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 15 October 2018Source: Drug Discovery Today: Disease ModelsAuthor(s): Stella Nyamoya, Felix Schweiger, Markus Kipp, Tanja HochstrasserAxonal damage is believed to be the main factor contributing to disease progression in multiple sclerosis patients. The degeneration of axons could be the result of several different harmful events including inflammation and demyelination. Details of the mechanisms leading to axonal damage are, however, unknown, and distinct preclinical animal models can be used to study mechanisms operant during axonal injury development and progression. In this review art...
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research
Conclusions DMF is associated with increased transitional and IL10+ and TGFβ+ regulatory B cells and a shift toward a more anti-inflammatory immune profile. Cell activation with reduced costimulatory capacity may induce immune hyporesponsiveness. Carryover effects of preceding therapies in 2nd-line patients and the stage of disease influence the immune profile of the patients and the immunomodulatory effects of DMF.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Multiple sclerosis Article Source Type: research
Publication date: Available online 14 October 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Cinzia Tiloca, Melissa Sorosina, Federica Esposito, Silvia Peroni, Claudia Colombrita, Nicola Ticozzi, Antonia Ratti, Filippo Martinelli Boneschi, Vincenzo Silani
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 12 October 2018Source: Autoimmunity ReviewsAuthor(s): Gwendoline Montes Diaz, Raymond Hupperts, Judith Fraussen, Veerle SomersAbstractMultiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which demyelination and neurodegeneration occurs. The immune system of MS patients is characterized by a dysregulation in the balance between pro- and anti-inflammatory immune cells, whereby both the innate and adaptive immune system are involved. Dimethyl fumarate (DMF) was licensed in 2013 as an oral first-line therapy for relapsing-remitting (RR)MS...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
AbstractIdentification of non-invasive biomarkers of disease progression in multiple sclerosis (MS) is critically needed for monitoring the disease progression and for effective therapeutic interventions. Urine is an attractive source for non-invasive biomarkers because it is easily obtained in the clinic. In search of a urine metabolite signature of progression in chronic experimental autoimmune encephalomyelitis (EAE), we profiled urine at the chronic stage of the disease (day 45 post immunization) by global untargeted metabolomics. Using a combination of high-throughput liquid-and-gas chromatography with mass spectromet...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study represents the first report of the miR-455-5p acts as an anti-inflammatory role in MS, at least partially through targeting MyD88 and REL. This study may provide imp ortant information for the use of miR-455-5p as a novel strategy to improve the severity of disease and control inflammation and attack in MS patients.
Source: Immunogenetics - Category: Genetics & Stem Cells Source Type: research
Publication date: January 2019Source: Multiple Sclerosis and Related Disorders, Volume 27Author(s): Giorgio Biasiotto, Isabella Zanella
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Multiple sclerosis is an immune-mediated autoimmune disease of the central nervous system that develops in genetically susceptible individuals and likely requires environmental triggers. The autoantigens and molecular mimics triggering the autoimmune response in multiple sclerosis remain incompletely understood. By using a brain-infiltrating CD4+ T cell clone that is clonally expanded in multiple sclerosis brain lesions and a systematic approach for the identification of its target antigens, positional scanning peptide libraries in combination with biometrical analysis, we have identified guanosine diphosphate (GDP)–...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Publication date: Available online 4 October 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Giorgio Biasiotto, Isabella Zanella
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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