Funding for gene therapy to injured peripheral nerves
(University of Plymouth) Scientists from Plymouth University Peninsula Schools of Medicine and Dentistry have received funding from the Northcott Devon Medical Foundation to explore the potential of gene therapy as a way to enhance functional recovery following microsurgery for injured peripheral nerves.
A gene therapy startup that spun out of Nationwide Children's Hospital six months ago has raised $2.5 million toward testing a treatment for a form of muscular dystrophy in patients. Myonexus Therapeutics Inc. is the fourth company to come out of gene therapy research at the Columbus hospital and the only one located in Central Ohio. CEO Michael Triplett and COO Bruce Halpryn are based in New Albany, and all of the contract research it sponsors takes place at Children's. “ The clinical impact…
SAN FRANCISCO, Dec. 13, 2017 -- (Healthcare Sales &Marketing Network) -- Audentes Therapeutics, Inc. (Nasdaq: BOLD), a biotechnology company focused on developing and commercializing gene therapy products for patients living with serious, life-threatenin... Biopharmaceuticals, Personnel Audentes Therapeutics, gene therapy, X-Linked Myotubular Myopathy
Publication date: Available online 12 December 2017 Source:Stem Cell Research Author(s): Yanlin Wang, Na Jing, Linlin Su, Changhe Shi, Pei Zhang, Zhilei Wang, Huifang Sun, Jing Yang, Yutao Liu, Xuejun Wen, Jin Zhang, Shoutao Zhang, Yuming Xu Skin fibroblasts were obtained from a 42-year-old Alzheimer's disease (AD) patient carrying mutations in the PSEN1 gene. An iPSC line was successfully established using the Sendai-virus (SeV) delivery system. The patient-specific iPSCs were free of genomically integrated reprogramming genes, had the specific mutation, expressed the expected pluripotency markers, and had the potential ...
In conclusion, these findings suggest that interference with PLCγ2 expression could relieve the inhibitory effect of PLCγ2 on hepaocyte apoptosis, thus promote proliferation through inactivating PKCδ‐mediated JNK1/2 signaling pathway. This article is protected by copyright. All rights reserved
Condition: Hemophilia B Intervention: Biological: FLT180a Sponsor: University College, London Not yet recruiting
PARIS, December 12, 2017 -- (Healthcare Sales &Marketing Network) -- Eyevensys, a clinical stage biotech company developing non-viral gene therapies for ophthalmic diseases, today announced the appointment of Dr. Patricia Zilliox as CEO. Dr. Zilliox, ... Biopharmaceuticals, Ophthalmology, Personnel Eyevensys, EyeCET, gene therapy, electro-transfection injection
LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer, Published online: 12 December 2017; doi:10.1038/s41417-017-0003-0LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer
LncRNA-SNHG16 predicts poor prognosis and promotes tumor proliferation through epigenetically silencing p21 in bladder cancer, Published online: 12 December 2017; doi:10.1038/s41417-017-0006-xLncRNA-SNHG16 predicts poor prognosis and promotes tumor proliferation through epigenetically silencing p21 in bladder cancer
Netrin-1 elicits metastatic potential of non-small cell lung carcinoma cell by enhancing cell invasion, migration and vasculogenic mimicry via EMT induction, Published online: 12 December 2017; doi:10.1038/s41417-017-0008-8Netrin-1 elicits metastatic potential of non-small cell lung carcinoma cell by enhancing cell invasion, migration and vasculogenic mimicry via EMT induction
by Sudhir Kumar Rai, Maya Sangesland, Michael Lee Jr., Caroline Esnault, Yujin Cui, Atreyi Ghatak Chatterjee, Henry L. Levin Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the selection of integration sites associated with promoters. The LTR-retrotransposon Tf1 ofSchizosaccharomyces pombe is studied as a model for oncogenic retroviruses because it integrates into the promoters of stress response genes. Although integrases (INs) encoded by retroviruses and LTR-retrotransposons ...