Sensing viral invasion by RIG-I like receptors.

Sensing viral invasion by RIG-I like receptors.
Curr Opin Microbiol. 2014 Jun 23;20C:131-138
Authors: Yoo JS, Kato H, Fujita T
Abstract
Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.
PMID: 24968321 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - June 23, 2014 Category: Microbiology Authors: Yoo JS, Kato H, Fujita T Tags: Curr Opin Microbiol Source Type: research