Antibiotic Doesn ’ t Prevent Lung Complication After Stem Cell Transplant

Findings were so dismal that clinical trial was stopped early
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Infections, Oncology, Pharmacy, Pulmonology, Research, News, Source Type: news

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In the present study, we have provided convincing evidence in vitro and in vivo demonstrating thatNr5a2 can induce lung cancer stem cells (CSC) properties and promote tumorigenesis and progression through transcriptional up ‐regulation of Nanog. AbstractLung cancer has the highest mortality rate due to late diagnosis and high incidence of metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self ‐renewal capability similar to that of normal stem cells (NSCs). While CSCs may play an important role in cancer progression, mechanisms underlying CSC self‐renewal and the relationship between self‐rene...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with cellular and fibrotic non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans (BO) sixteen years after hematopoietic stem cell transplantation. Histological examination revealed almost exclusive infiltration of CD3-positive T lymphocytes associated with lymphoepithelial lesions and multi-focal denudation of covering epithelial cells in all components. This case suggests PPFE, NSIP, and BO might be conditions of the same spectrum, pathogenetically related to chronic graft-versus-host disease. Immun...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation, Published online: 05 February 2019; doi:10.1038/s41379-019-0203-2Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation
Source: Modern Pathology - Category: Pathology Authors: Source Type: research
Early detection of lung abnormalities following hematopoietic stem cell transplant (HSCT) remains a challenge primarily due to the insensitivity of spirometry, the current clinical gold standard, to mild changes. This insensitivity carries through to assessing treatment response and personalizing pulmonary interventions for HSCT patients. Hyperpolarized 129Xe magnetic resonance imaging (MRI) has been demonstrated to be sensitive to early regional airway obstruction, and as a modality free of ionizing radiation, we hypothesized that serial 129Xe MRI could gauge treatment response in pediatric HSCT patients.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 368 Source Type: research
Graft-versus-host disease (GVHD) of the lung, also known as bronchiolitis obliterans syndrome (BOS), is associated with high mortality, but treatment with the combination of fluticasone, azithromycin, and montelukast (FAM) stabilizes lung function in the majority of patients. Recently, a randomized controlled trial evaluating azithromycin given at the time of conditioning for GVHD prevention was closed prematurely due to an increased risk of cancer relapse in azithromycin recipients. We evaluated whether exposure to azithromycin after allogeneic hematopoietic cell transplantation (allo-HCT), primarily for treatment of BOS,...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 326 Source Type: research
GVHD is a result of immune attack of host tissues, such as the skin, gut, liver, and lung, by various immune cells in hematopoietic stem cell transplantation (HSCT). Chronic GVHD (cGVHD) is the main cause of late death and morbidity after allogeneic HSCT. Fibrosis constitutes the end stage of the inflammatory process in cGVHD leading to major morbidity. Recently, segregated-nucleus-containing atypical monocytes (SatM) that involved in lung fibrosis has been identified. We hypothesized that SatM involved in tissue fibrosis of chronic GVHD after bone marrow transplantation.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 434 Source Type: research
Authors: Das A, Kumar A, Arrossi AV, Ghosh S, Highland KB Abstract INTRODUCTION: Interstitial lung disease (ILD) is the most common cause of mortality in systemic sclerosis; accounting for approximately 35% of deaths. Although immunosuppression is currently opted as first line therapy for scleroderma-related ILD (SSc-ILD), the benefits from it remain modest with concerns for systemic toxicity from long term use. Areas covered: We review the important facets in monitoring a patient with SSc-ILD, including recognizing various patterns of ILD, identifying those at risk for disease progression and discuss the strength ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortal...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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