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Antibiotic Doesn ’ t Prevent Lung Complication After Stem Cell Transplant

Findings were so dismal that clinical trial was stopped early
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Infections, Oncology, Pharmacy, Pulmonology, Research, News, Source Type: news

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This study aimed to present radiological, histological, and clinical characteristics of IPS.Methods: We evaluated medical records of 1221 patients who underwent HSCT between 2003 and 2016 at our hospital and identified those who subsequently developed IPS as diagnosed based on the American Thoracic Society’s 2012 definitions.Results: Thirty-six patients were diagnosed with IPS. No patient showed findings of active lower respiratory infection or pulmonary edema. The median time from transplantation to the development of IPS was 215 days. Radiologically, ground-glass opacity (GGO) was the most common finding, seen in 2...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
Introduction: Deterioration in muscle strength, exercise capacity and quality of life (QOL) may result from chemotherapy, radiotherapy, corticosteroids use before hematopoietic stem cell transplantation (HSCT) and transplantation itself. Limited number of study investigated dyspnea, pulmonary functions, maximal exercise capacity and QOL in allogeneic HSCT recipients.Aim: To compare dyspnea, pulmonary functions, maximal exercise capacity and QOL in allo-HSCT recipients with healthy controls.Methods: Fifty-one recipients (post-transplantation100 days) (38.26±13.78y, 18F) and 52 controls (34.73±11.07y, 22F) were...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Transplantation of bone marrow mesenchymal stem cells (MSCs) has been identified as one such possible strategy for treatment of lung diseases including acute lung injury (Guan XJ., et al. 2012). Terapeutic potential of the MSCs lies in their paracrins effects with underlie their ability to enchance tissue regeneration and modulate immune responces (Rankin S.,2012).The aim of this study was to evaluate the effectiveness of transplantation of MSCs (TMSCs) on the dynamics of proinflammation cytokines (IF, IL-6), integral parameters of quality of life psychic and physic health (IPPH, IPPhH), distantion in 6-min wolking test (6...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and Chronic Care Source Type: research
Macrophages harbor great plasticity and adapt effectively to specific environmental factors. Here, we analyzed the adaptation of induced pluripotent stem cell (iPSC) derived macrophages to the lung environment. Human iPSC derived macrophages were transplanted intrapulmonary to humanized Pulmonary Alveolar Proteinosis (PAP) mice which display high pulmonary levels of surfactant and human GM-CSF. PAP is a life-threatening lung disease caused by GM-CSF receptor mutations and a differentiation block of alveolar macrophages (AM).Mice were transplanted four times in four consecutive weeks, and iPSC macrophages were re-isolated a...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric Bronchology Source Type: research
In this study, we integrated atomic force microscopy (AFM) and molecular approaches to determine whether increased stiffness of aortic VSMCs in hypertensive rats is ROCK-dependent, and whether the anti-hypertensive effect of ROCK inhibitors contributes to the reduction of aortic stiffness via changing VSMC mechanical properties. Despite a widely held belief that aortic stiffening is associated with changes in extracellular matrix proteins and endothelial dysfunction, our recent studies demonstrated that intrinsic stiffening of aortic VSMCs, independent of VSMC proliferation and migration, is an important contributo...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Infection by Nocardia species is an uncommon cause of severe clinical syndromes, particularly in immunocompromised patients, and solid-organ transplantation is the most common underlying condition. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been described thus far in lung and stem cell transplants with systemic nocardiosis.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: Original Contributions: Case Reports Source Type: research
Conclusion: Hypoxia enhances the therapeutic effect of mesenchymal stromal cells on radiation-induced lung injury by promoting MSC proliferation and improving their antioxidant ability, mediated by HIF-1 α.Cell Physiol Biochem 2017;44:1295 –1310
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities. The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Despite intensive cancer treatment, our analysis showed modest reductions in obstructive parameters among long-term LSs after HDT-ASCT compared to normative reference data. To limit obstructive impairments in LSs after HDT-ASCT, we suggest that targeted smoking-cessation advice is directed towards patients who have received high cumulative doses of doxorubicin. PMID: 29171324 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
This study was conducted to examine whether exercise training potentiates the cardioprotective effects of adipose-derived stem cell (ADSC) transplantation following myocardial infarction (MI) in rats.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Original Article Source Type: research
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