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Antibiotic Doesn't Prevent Lung Complication After Stem Cell Transplant

Findings were so dismal that clinical trial was stopped early
Source: Cancercompass News: Other Cancer - Category: Cancer & Oncology Source Type: news

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Introduction: Deterioration in muscle strength, exercise capacity and quality of life (QOL) may result from chemotherapy, radiotherapy, corticosteroids use before hematopoietic stem cell transplantation (HSCT) and transplantation itself. Limited number of study investigated dyspnea, pulmonary functions, maximal exercise capacity and QOL in allogeneic HSCT recipients.Aim: To compare dyspnea, pulmonary functions, maximal exercise capacity and QOL in allo-HSCT recipients with healthy controls.Methods: Fifty-one recipients (post-transplantation100 days) (38.26±13.78y, 18F) and 52 controls (34.73±11.07y, 22F) were...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
In this study, we integrated atomic force microscopy (AFM) and molecular approaches to determine whether increased stiffness of aortic VSMCs in hypertensive rats is ROCK-dependent, and whether the anti-hypertensive effect of ROCK inhibitors contributes to the reduction of aortic stiffness via changing VSMC mechanical properties. Despite a widely held belief that aortic stiffening is associated with changes in extracellular matrix proteins and endothelial dysfunction, our recent studies demonstrated that intrinsic stiffening of aortic VSMCs, independent of VSMC proliferation and migration, is an important contributo...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Hypoxia enhances the therapeutic effect of mesenchymal stromal cells on radiation-induced lung injury by promoting MSC proliferation and improving their antioxidant ability, mediated by HIF-1 α.Cell Physiol Biochem 2017;44:1295 –1310
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities. The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Despite intensive cancer treatment, our analysis showed modest reductions in obstructive parameters among long-term LSs after HDT-ASCT compared to normative reference data. To limit obstructive impairments in LSs after HDT-ASCT, we suggest that targeted smoking-cessation advice is directed towards patients who have received high cumulative doses of doxorubicin. PMID: 29171324 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Our discoveries raise an intriguing question of the role of β-catenin in EGFR-TKIs-treated cancer stem cell-like population(s) and its potential as a new therapeutic target for NSCLC in the future. PMID: 29154817 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
Purpose of review: To describe primary immunodeficiencies caused by gain-of-function (GOF) mutations of signal transducer and activator of transcription (STAT) genes, a group of genetically determined disorders characterized by susceptibility to infections and, in many cases, autoimmune manifestations. Recent findings: GOF mutations affecting STAT1 result in increased STAT tyrosine phosphorylation and secondarily increased response to STAT1-signaling cytokines, such as interferons. In contrast, STAT3 hyperactivity is not usually related to hyperphosphorylation but rather to increased STAT3-mediated transcriptional activit...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by David B. Lewis Source Type: research
That’s the title of a very interesting BBC News article I read this morning, thanks to my friend Paul: goo.gl/pkXS1J It’s about two recent studies that examined patients with cancer (1. lung or kidney; 2. melanoma), discovering that those who had a lot of “friendly” gut bacteria responded better to immunotherapy. Excerpt: Dr Jennifer Wargo, from Texas, told the BBC: “If you disrupt a patient’s microbiome you may impair their ability to respond to cancer treatment.” Okay, so the patients in the two studies didn’t have myeloma. But I would bet anything that those three typ...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll BBC News Clostridium difficile gut bacteria microbiome probiotics SCT Source Type: blogs
Radiation therapy is an important treatment modality for multiple thoracic malignancies. However, radiation‐induced lung injury (RILI), which is the term generally used to describe damage to the lungs caused by exposure to ionizing radiation, remains a critical issue affecting both tumor control and patient quality of life. Despite tremendous effort, there is no current consensus regarding the optimal treatment approach for RILI. Because of a number of functional advantages, including self‐proliferation, multi‐differentiation, injury foci chemotaxis, anti‐inflammation, and immunomodulation, mesenchymal stem cells (...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: MINI REVIEW Source Type: research
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