Primary decompressive craniectomy is associated with worse neurological outcome in patients with traumatic brain injury requiring acute surgery.

CONCLUSION: In conclusion, patients requiring primary decompressive craniectomy had a higher risk for poor neurological outcome compared to patients undergoing craniotomy or were conservatively treated. It is plausible that the poor prognosis is related to the TBI severity itself rather than the intervention. Further prospective randomized trials are required to establish the role of decompressive craniectomy in the treatment of patients with TBI. PMID: 28781918 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

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CONCLUSIONS: UPF1 is down-regulated in glioma and alleviates the progression of glioma via targeting CYTOR. PMID: 31799670 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
AbstractSphenoid wing dural AVFs represent a rare clinical entity. These lesions may be asymptomatic or present with focal neurologic deficits, intracranial venous hypertension, or intracranial hemorrhage. Diagnosis is based on clinical findings and diagnostic imaging. They are alternatively classified as lesions of either the greater or lesser wings of the sphenoid bone. We performed a search of the PubMed database of studies evaluating the clinical behavior and surgical and endovascular therapies of these lesions. Dural AVFs draining into the superficial middle cerebral vein and/or laterocavernous sinus, or rather, lesio...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Conditions:   Meningioma;   Tumor, Brain;   Chiari Malformation;   Vascular Malformation;   Hydrocephalus;   Tethered Cord;   Dural Fistula;   Craniotomy;   Spinal Surgery;   Duraplasty Intervention:   Sponsor:   Aesculap AG Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article provides step-by-step descriptions of our surgical technique for non-lesional FLE. Sixteen patients undergoing eFL were included in this study. The goals were to maximize gray matter removal, including the orbital gyrus and subcallosal area, and to spare the primary motor and premotor cortexes and anterior perforated substance. The eFL consists of three steps: (1) positioning, craniotomy, and exposure; (2) lateral frontal lobe resection; and (3), resection of the rectus gyrus and orbital gyrus. Resection ahead of bregma allows preservation of motor and premotor area function. To remove the orbital gyrus preser...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Publication date: Available online 4 December 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Ho Yan Zheng, Senthil Kumar, Mohd Sofan ZenianAbstractPlasma cell neoplasms can present either as multiple myeloma, or in
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
AbstractBackgroundPrevious studies have not evaluated the impact of illness severity and postrupture procedures in the cost of care for intracranial aneurysms. We hypothesize that the severity of aneurysm rupture and the aggressiveness of postrupture interventions play a role in cost.MethodsThe Value Driven Outcomes database was used to assess direct patient cost during the treatment of ruptured intracranial aneurysm with clipping, coiling, and Pipeline flow diverters.ResultsOne hundred ninety-eight patients (mean age 52.8  ± 14.1 years; 40.0% male) underwent craniotomy (64.6%), coiling (26.7%), o...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
CONCLUSION POD is prevalent in patients after elective intracranial surgery. The identified risk factors for and the potential association of POD with adverse outcomes suggest that a comprehensive strategy involving screening for predisposing factors and early prevention of modifiable factors should be established in this population. TRIAL REGISTRATION ClinicalTrials.gov NCT03087838.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Perioperative medicine Source Type: research
AbstractSurgical access to lesions in the fourth ventricle may be achieved utilizing transvermian or transtelovelar trajectories. We performed a search of the PubMed database for studies describing the microsurgical details and evaluating the clinical utility of the telovelar surgical approach. The telovelar approach has proven to be  a safe, effective, and versatile alternative to the transvermian approach. The operative strategy utilizes midline suboccipital craniotomy without or with C1 laminectomy, followed by cerebellar hemispheric and tonsillar retraction, and wide durotomy. Access is generously provided to...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Conclusion: The maintenance of systemic physiological homeostasis by anticipation of complications, vigilant monitoring, and prompt resuscitation is critical to foster favorable outcomes in unison with optimal and safe surgical extirpation of the primary cerebral lesion.
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
ConclusionsIn all cognitive domains, except for psychomotor speed, cognitive functioning can be preserved after awake surgery. The domain of psychomotor speed seems to be most vulnerable to the effects of surgery and early postoperative therapies. Cognitive performance after glioma surgery is associated with a combination of structural and biomolecular effects from the tumor, including IDH-status and left thalamic involvement.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
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