Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature.

CONCLUSION: Fluorescein seems to be safe and effective in the resection of HGGs, allowing a high rate of gross total removal of contrast enhanced areas. PMID: 28781922 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

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CONCLUSIONS Propofol can suppress cell growth and metastasis by regulating the miR-410-3p/TGFBR2 axis in glioma. PMID: 31960827 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In this study, the authors evaluated the incidence, risk factors, and long-term implications of intraoperative ischemic events. METHODS: The authors retrospectively evaluated patients who had undergone resection of an LGG between 2013 and 2017. Analysis included pre- and postoperative demographic, clinical, radiological, and anesthetic data, as well as intraoperative neurophysiology data, overall survival, and functional and neurocognitive outcomes. RESULTS: Among the 82 patients included in the study, postoperative diffusion-weighted imaging showed evidence of acute ischemic strokes in 19 patients (23%), 13 of w...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
ConclusionsA delay in diagnosis or lack of a diagnosis in pheochromocytoma and paraganglioma may increase the perioperative morbidity and mortality risk due to excess catecholamine secretion. Therefore, routine pheochromocytoma and paraganglioma screening preoperatively in patients with neurofibromatosis type 1 is very important.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Surgery of GBM nowadays is usually performed under general anesthesia (GA) and resections are often not as aggressive as possible, due to the chance of seriously damaging the patient with a rather low life expectancy. A surgical technique optimizing resection of the tumor in eloquent areas but preventing neurological deficits is necessary to improve survival and quality of life in these patients. Awake craniotomy (AC) with the use of cortical and subcortical stimulation has been widely implemented for low-grade glioma resections (LGG), but not yet for GBM.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research
AbstractPurposeReducing the time from surgery to adjuvant chemoradiation, by decreasing unnecessary readmissions, is paramount for patients undergoing glioma surgery. The effects of intraoperative risk factors on 30-day readmission rates for such patients is currently unclear. We utilized a predictive model-driven approach to assess the impact of intraoperative  factors on 30-day readmission rates for the cranial glioma patient.MethodsRetrospectively, the intraoperative records of 290 patients who underwent glioma surgery at a single institution by a single surgeon were assessed. Data on operative variables including ...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
This study clarifies that sevoflurane inhibits proliferation, invasion, and migration, and promotes apoptosis in glioma cells. These effects are regulated by IGF-1, an upstream gene of the PI3K/AKT signaling pathway. These findings may be significant for the selection of anesthetic agents in glioma surgery to improve the prognosis of patients.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Publication date: Available online 2 July 2019Source: NeuroImage: ClinicalAuthor(s): Adam Kenji Yamamoto, Joerg Magerkurth, Laura Mancini, Mark J. White, Anna Miserocchi, Andrew W. McEvoy, Ian Appleby, Caroline Micallef, John S. Thornton, Cathy J. Price, Nikolaus Weiskopf, Tarek A. YousryAbstractWe evaluated whether task-related fMRI (functional magnetic resonance imaging) BOLD (blood oxygenation level dependent) activation can be obtained under conventional anaesthesia at a depth enabling neurosurgery in five patients with supratentorial gliomas. Within a 1.5 T MRI operating room immediately prior to neurosurgery, a pas...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas.Methods This was an interventional, parallel assignment, nonrandomized trial. Study subjects were admitted in the operating room. Patients with supratentorial eloquent area gliomas and volunteers of similar age without neurologic disease were sedated with midazolam, but still responsive and cooperative. Motor and sensory functions for upper extremities were evaluated by the Nine-Hole Peg Test before and after...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
CONCLUSIONSCurrent subjective methods for assessing wakefulness during awake craniotomies may be insufficient. The administration of objective measures of wakefulness just prior to language task administration may help to ensure that patients are ready for testing. It may also allow neurosurgeons to identify patients who are at risk for poor intraoperative performance. PMID: 31151102 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Conclusions: The present study demonstrates that hyperpolarized 13C MRS potentially can be used to identify and characterize gliomas that are 18F-FDG negative. The Lac/Bic imaging marker is interesting because it reports on the ratio between increased glycolysis (Warburg effect) and the more ATP favorable oxidative phosphorylation inside the cells3. Further histological analysis will be performed to get better understanding how the metabolic differences correlate with the proliferative state of the tumor. Acknowledgements NIH grants R01CA176836, R01EB019018, P41EB01589, S10OD012283, S10OD018130-01 GE HealthcareLucas Founda...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Multimodality and Nonradioactive Probes Posters Source Type: research
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