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One step closer in explaining MS relapse during upper respiratory infection

(University of Illinois College of Agricultural, Consumer and Environmental Sciences) For most of us, the flu is just the flu. We suffer through it for several days, and eventually bounce back. But for patients with multiple sclerosis (MS) and other neurological diseases, the flu can trigger a cascade of immune responses that result in a full-blown relapse of the disease. In a recent study, Illinois researchers shed light on what may be happening in the brains of MS patients during upper respiratory infections.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus JC (JCV). The aim of this study was to explore natalizumab-induced phenotypic changes in peripheral blood T-lymphocytes and their relationship with JCV reactivation. Forty-four patients affected by RRMS were enrolled. Blood and urine samples were classified according to natalizumab infusion number: 0 (N0), 1-12 (N12), 13-24 (N24), 25-36 (N36), and ov...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractPurpose of reviewThis review will examine the current evidence that genetic and/or epigenetic variation may influence the multiple sclerosis (MS) clinical course, phenotype, and measures of MS severity including disability progression and relapse rate.Recent findingsThere is little evidence that MS clinical phenotype is under significant genetic control. There is increasing evidence that there may be genetic determinants of the rate of disability progression. However, studies that can analyse disability progression and take into account all the confounding variables such as treatment, clinical characteristics, and ...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
ConclusionsOverall, most respondents would follow the ONTT guidelines regarding IV methylprednisolone. There was a significant difference in responses between the ophthalmologists and neurologists regarding who to treat, duration of treatment and appropriate investigations.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
New guidelines update guidance on starting, switching, and stopping disease-modifying therapies in multiple sclerosis and recommend an earlier, rather than later, start to treatment.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
(MedPage Today) -- AAN updates multiple sclerosis treatment recommendations
Source: MedPage Today Neurology - Category: Neurology Source Type: news
The Paced Auditory Serial Addition Test (PASAT) is widely used to evaluate processing speed and executive function in patients with multiple sclerosis, traumatic brain injury, and other neurological disorders. In the PASAT, subjects listen to sequences of ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Conclusions: The brain health index is a new image analysis approach that may usefully capture combined visible brain damage in large-scale studies of ageing, neurovascular and neurodegenerative disease. The Study in Context: Next: Brain scans to identify children at high risk of developing multiple sclerosis (MS) before symptoms appear 25 Key Resources to Improve Brain Health and Mental Health Five reasons the future of brain enhancement is digital, pervasive and (hopefully) bright 10 neurotechnologies about to transform brain enhancement and brain health What are cognitive abilities and how to boost them? Solving ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology atrophy brain health index Brain-health brain-injury cerebral small vessel diseases cognition computer-assisted image processing magnetic resonance imaging stroke Source Type: blogs
MONDAY, April 23, 2018 -- Most multiple sclerosis patients shouldn't wait to start taking medication in the early stages of the disease, new guidelines say. " The treatment landscape for people with MS has changed dramatically over the last decade, " ...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Condition:   Multiple Sclerosis Intervention:   Other: Task-oriented training Sponsor:   Gazi University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Roche announced today that new OCREVUS (ocrelizumab) data were presented at the 70th American Academy of Neurology (AAN) Annual Meeting from 21-27 April in Los Angeles, California.
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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