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One step closer in explaining MS relapse during upper respiratory infection

(University of Illinois College of Agricultural, Consumer and Environmental Sciences) For most of us, the flu is just the flu. We suffer through it for several days, and eventually bounce back. But for patients with multiple sclerosis (MS) and other neurological diseases, the flu can trigger a cascade of immune responses that result in a full-blown relapse of the disease. In a recent study, Illinois researchers shed light on what may be happening in the brains of MS patients during upper respiratory infections.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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CONCLUSION: Future studies are needed to explore the role of EVI5 in the pathogenesis of MS. PMID: 29036808 [PubMed - as supplied by publisher]
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
We describe how we designed a way of involving people in a particular piece of health economics research.The aim of the work was to produce descriptions of different states of health experienced by people with multiple sclerosis (MS). These descriptions have since been rated in terms of how good or bad they are in a way that can be used by the National Institute for Health and Care Excellence (NICE) to make decisions about what services to fund on the NHS.We formed a panel of three people with MS, and designed a task to help the group produce health descriptions likely to be experienced by people with MS. After discussion ...
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
Conclusions: We describe the clinical characteristics and outcomes of children with incidental MRI findings highly suggestive of CNS demyelination. Children with RIS had a substantial risk of subsequent clinical symptoms and/or radiologic evolution. The presence of oligoclonal bands in CSF and spinal cord lesions on MRI were associated with an increased risk of a first clinical event. News in Context Next: Harnessing brain scans to personalize autism-related behavioral interventions Can brain scans identify ADHD and help predict treatment response? Brain waves help predict stress-related sleep problems Cognitive therapy ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology brain changes brain-scans clinical headache MRI MS multiple-sclerosis radiologic radiologically isolated syndrome RIS Source Type: blogs
A large-scale new study found that concussions in adolescents can increase the risk of later developing multiple sclerosis.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Athletics and Sports Concussions Multiple Sclerosis Sports Injuries Teenagers and Adolescence Source Type: news
(Heinrich-Heine University Duesseldorf) A scientific collaboration between stem cell researchers of the Heinrich-Heine-University Duesseldorf, Germany, led by Professor Patrick K ü ry (Neurology) and by Professor James Adjaye (Stem Cell Research and Regenerative Medicine) with support from British and Chilean colleagues resulted in a publication on the prospective use of stem cells to generate cell replacement in diseases such as multiple sclerosis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions Our meta-analysis showed that modafinil was an effective pharmacologic therapy for MS fatigue. Additional research is required to determine optimal dosing and treatment schedules.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
This study included 132 people with MS (PwMS) (80 women), mean EDSS 2.9 (S.D.=1.7). Depression was assessed by the Hospital Anxiety and Depression Scale questionnaire. Spatio-temporal parameters of gait were studied using an electronic walkway. Participants filled out a valid self-rated measure of walking ability, the Multiple Sclerosis Walking Scale (MSWS-12) questionnaire. Computerized cognitive scores were included in the analysis in a multivariable analysis. Forty PwMS (30.3%) were classified as suffering from depression. Individuals in the depressed group walked slower than those in the non-depressed group; 92.2 (S.D=...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusions: These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937 Received: 21 March 2017 Revis...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
In this study, 36 RR-MS patients in the remission phase took part. We analyzed two subgroups of RR-MS: one, 1 to 2  months after completing steroid treatment during relapse (post-acute;n = 13) and the other, over 2 years without any relapse (stable;n = 23). Moreover, we made correlations between these biochemical results and clinical parameters of cognitive impairment, depression, and disability. The obtained results presented downregulation of miR-155 and miR-301a (in 94% and 51% samples, respectively) and overexpression of miR-326 (in 72% s amples) in RR-MS patients. Moreover, we observed a ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Clinical course in multiple sclerosis (MS) is difficult to predict on group and individual levels. We discuss the topographical model of MS as a new approach to characterizing the clinical course, with the potential to personalize disability progression based on each individual patient ’s pattern of disease burden (eg, lesion location) and reserve. The dynamic clinical threshold depicted in this visual model may help clinicians to educate patients about clinical phenotype and disease burden, and foster an understanding of the difference between relapses and pseudoexacerbations. There is an emphasis on building reserv...
Source: Neurologic Clinics - Category: Neurology Authors: Source Type: research
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