Probiotics in Infancy Do Not Reduce Incidence of Eczema
Probiotics in first six months of life do not reduce incidence of eczema at age 2, asthma at age 5
Conclusions Self-reported adult-onset AD is common and has distinct phenotypes with lesional predilection for the hands and/or head/neck.
Conclusions Asthma at age 4 years is twice as common in those with challenge-proven food allergy at age 1 year, irrespective of whether the food allergy subsequently resolves. Children with 2 or more food allergies and those with coexistent eczema were almost 3 times as likely to develop asthma compared with those with no food allergies.
Industrialized countries have registered epidemic rates on allergic diseases, such as hay fever, asthma, eczema, and food allergies. The Hygiene Hypothesis was born from work made by Dr. David Strachan, who observed that younger siblings were less susceptible to eczema and asthma, and proposed that this was a result of increased transmission of infectious agents via unhygienic practices within a household. This initial hypothesis was then reframed as the old friends/microbiota hypothesis, implicating non-pathogenic commensal microorganisms as the source of immunomodulatory signals necessary to prevent immune-mediated chronic disorders.
Conclusions: As restaurant cook, the patient had had to taste milk containing dishes up to 200 x per working day. Since he hadn't been exposed to cow milk before entering the job we concluded, that the food allergy and asthma had been caused by his occupation. To our knowledge this is the first case for occupational asthma by ingestive allergens in Germany.
Introduction: Risk factors for multimorbidity are poorly understood in young children with different wheezing phenotypes.Objectives: To evaluate risk factors for multimorbidity in different wheezing phenotypes.Methods: Cross-sectional analysis of 360 outpatient children, ≤5 yrs, 59% males, with current wheezing (symptoms referred in the last 12 months).We defined multimorbidity as the coexistence ≥2 of these conditions: eczema, rhinitis, oral allergy syndrome, urticaria, angioedema, food allergy, otitis, sinusitis, sleep disorders based on structured questionnaires filled by parents. Relationships of multimorbidity w...
Conclusion: Whilst atopic diseases and internalizing disorders are highly genetic in aetiology, genes do not appear to explain the comorbidity of these diseases.
Background: Asthma is the commonest medical reason for a child to be admitted to hospital in the UK. c.15% are readmitted within 3 months.Aim: We undertook a retrospective case-control study to determine the predictors of readmission.Methods: We retrieved the medical notes of 35 children readmitted within 90 days following an admission for asthma (cases). We randomly selected 35 children with asthma who were not readmitted (controls). We recorded: age, gender, ethnicity, history of eczema, hayfever or rhinitis, parental smoking status, pet ownership, number of siblings, previous admissions, postcode, age-corrected respirat...
Conclusion: Application of a SPT panel including 4 allergens in children referring with asthma is adequate for detection of most of the sensitized children in tropical countries.
Background: Pathophysiology of asthma in preschool children (
Conclusion: In this cohort of UK preschool children we found no evidence that ICS or LTRA therapy is associated with fewer exacerbations during 1 outcome year.