Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition

Inflammasomes were proposed to shape gut ecology based on dysbiosis in mutant mice versus non-littermate wild-types. Mamantopoulos et  al. show that inflammasomes do not affect gut microbiota composition when controlling for non-genetic confounders. This finding dismisses the suggested role for inflammasomes in controlling host health through regulation of intestinal ecology.

Source: Immunity - August 8, 2017 Category: Allergy & Immunology Authors: Michail Mamantopoulos, Francesca Ronchi, Filip Van Hauwermeiren, Sara Vieira-Silva, Bahtiyar Yilmaz, Liesbet Martens, Yvan Saeys, Stefan K. Drexler, Amir S. Yazdi, Jeroen Raes, Mohamed Lamkanfi, Kathy D. McCoy, Andy Wullaert Tags: Article Source Type: research