Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action
Although glucocorticoids are widely used anti-inflammatory drugs, relevant mechanisms are unclear. Oh et al. monitored the epigenomic landscape of macrophages and found that the gene-inducing activity of GR is crucial for boosting inhibitors of inflammatory factors. This cautions the idea that GR ligands selectively promoting trans-repression should improve therapeutic outcome.
Source: Immunity - Category: Allergy & Immunology Authors: Kyu-Seon Oh, Heta Patel, Rachel A. Gottschalk, Wai Shing Lee, Songjoon Baek, Iain D.C. Fraser, Gordon L. Hager, Myong-Hee Sung Tags: Article Source Type: research
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