Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

Although glucocorticoids are widely used anti-inflammatory drugs, relevant mechanisms are unclear. Oh et  al. monitored the epigenomic landscape of macrophages and found that the gene-inducing activity of GR is crucial for boosting inhibitors of inflammatory factors. This cautions the idea that GR ligands selectively promoting trans-repression should improve therapeutic outcome.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research