Antipsychotic Polypharmacy With Risperidone and Olanzapine Antipsychotic Polypharmacy With Risperidone and Olanzapine

Given high rates of treatment failure for initial therapy of schizophrenia, is combining risperidone and olanzapine an appropriate approach to improve clinical response and limit adverse effects?Medscape Pharmacists
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pharmacist Ask the Expert Source Type: news

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A new paper in Journal of Clinical Psychology is the just the latest to take a trans-diagnostic approach to mental health By Alex Fradera The number of psychiatric diagnoses keep on growing, with perhaps ten times as many categories now as there were 50 years ago. This may in part reflect our growing knowledge, which is welcome. But the sheer density of diagnoses makes it difficult for researchers or clinicians to see the wood for the trees, and it encourages them to settle into silos. It would be advantageous for clinical research and practice if we could introduce some elegance to our understanding. A recent movemen...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Mental health Source Type: blogs
CONCLUSIONS: The iterative co-creation process based upon a high degree of patient involvement resulted in a set of PROMs, a national measurement concept, and patient recommendations for implementation. The cooperation between patients and professionals was successful. PMID: 30015541 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Authors: Khalil AH, ELNahas G, Ramy H, Abdel Aziz K, Elkholy H, El-Ghamry R Abstract OBJECTIVE: To study the effect of a culturally adapted, structured family intervention on symptom severity, medication attitudes and knowledge, social functioning and quality of life in patients with schizophrenia. METHODS: Thirty subjects with schizophrenia were selected to receive 14 sessions of a culturally adapted behavioural family psychoeducational programme (BFPEP). Another 30 subjects received standard treatment as usual (STU) for 6 months. Pre- and post-intervention outcomes were assessed using the Positive and Negativ...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
This study investigated the relationship between hallucination proneness and the brain structure of the STG.Hallucination proneness was assessed by the Launey Slade Hallucination Scale (LSHS) in 25 healthy individuals who varied in their propensity to hear voices. Brain volume and microstructure of the STG was assessed by magnetic resonance imaging (MRI). Microstructure was examined by conventional diffusion-tensor imaging as well as by neurite orientation dispersion and density imaging (NODDI). The latter decomposes diffusion-based MRI into multiple compartments that characterize the brain microstructure by its neurite co...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
AbstractAlthough heatstroke commonly occurs in summer, herein, we present a case of heatstroke that occurred in March. The patient has been schizophrenic for over 20  years and has been receiving long-term medications, such as lithium carbonate, clozapine, and lorazepam. We analyzed the evolution of her cerebellar magnetic resonance imaging characteristics to determine the association of heatstroke in schizophrenia. Patients with schizophrenia are at high risk for developing heatstroke, possibly due to the use of antipsychotic drugs.
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Publication date: Available online 18 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): L. Ukkola-Vuoti, M. Torniainen-Holm, A. Ortega-Alonso, V. Sinha, A. Tuulio-Henriksson, T. Paunio, J. Lönnqvist, J. Suvisaari, W. HennahAbstractSchizophrenia is a heterogeneous disorder characterized by a spectrum of symptoms and many different underlying causes. Thus, instead of using the broad diagnosis, intermediate phenotypes can be used to possibly decrease the underlying complexity of the disorder. Alongside the classical symptoms of delusions and hallucinations, cognitive deficits are a...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Condition:   Recruitment, Invitation Letters, Patients With Schizophrenia Interventions:   Other: Old invitation letter;   Other: New invitation Letter Sponsor:   Aalborg Universitetshospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Peta-Gaye L. Thomas-Brown, Jacqueline S. Martin, Clayton A. Sewell, Wendel D. Abel, Maxine D. Gossell-Williams
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Li C, Tao H, Yang X, Zhang X, Liu Y, Tang Y, Tang A Abstract Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential serum biomarkers during first-episode psychosis (FEP) is especially helpful to understand the onset and prognosis of this disorder. To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The expression levels of Neuregulin1 (NRG1), ErbB4, brain-derived neurotrophic factor (BDNF), DNA methyltransferases 1 (DNMT1) and ten-eleven translocation 1 (TET1) proteins in peripheral blood of 53 FEP patients and 57 healthy cont...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Publication date: Available online 17 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jun Ju, Luping Liu, Yujie Zhang, Qiang ZhouAbstractIn humans, schizophrenia with onset in adolescence or adult has distinct features. To understand whether schizophrenia with either adolescence- or adult-onset have distinct phenotypes and cellular mechanisms in schizophrenia model mice, we altered Nrg1 signaling during either adolescence or adult mice via injection of anti-Nrg1 antibodies. We found that in either early-onset schizophrenia (EOS)- or late-onset schizophrenia (LOS)-like mice, certain...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
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