Antipsychotic Polypharmacy With Risperidone and Olanzapine Antipsychotic Polypharmacy With Risperidone and Olanzapine
Given high rates of treatment failure for initial therapy of schizophrenia, is combining risperidone and olanzapine an appropriate approach to improve clinical response and limit adverse effects?Medscape Pharmacists
Molecular Psychiatry, Published online: 17 October 2017; doi:10.1038/mp.2017.170
If it disagrees with experiment it is wrong. In that simple statement is the key to science. It does not make any difference how beautiful your guess is. It does not make any difference how smart you are, who made the guess, or what his name is – if it disagrees with experiment it is wrong. That is all there is to it.—Richard Feynman (1)
In this issue of Biological Psychiatry, Hartz et al. (1) report evidence for common genetic origins of schizophrenia and addiction using a relatively new method, the polygenic risk score (PRS). Genome-wide association (GWA) has implicated many single nucleotide polymorphisms (SNPs) and genes in psychiatric disease, but identified few functional loci, with notable exceptions, such as the CHRNA5 Asn398Asp locus in smoking, nearly simultaneously implicated by pathway analysis (2). Discovery of circuits, cells, and molecules integral to psychiatric diseases has been accomplished largely without the aid of GWA.
Previous research on moral judgement in healthy adults suggests a complex interplay of automatic, emotional and deliberative processing. We aimed to advance understanding of these processes by examining moral judgement in individuals with schizophrenia, a ...
This article aims to examine the effect of writing when used as self-medication in psychosis and particularly in schizophrenia. It is based on the work of Antonin Artaud, who engaged in writing to reduce his physical and psychological dissociation and intr...
Compared with those admitted for other medical conditions, patients admitted for epilepsy show increases in subsequent schizophrenia readmissions, a new study suggests.Medscape Medical News
Hospital discharge planning for clients with schizophrenia reduces client rehospitalization rates and improves their medication adherence. The effectiveness of caregiver participation in hospital discharge planning has seldom been explored. The purpose of this study was to examine the effectiveness of caregiver participation in hospital discharge planning for clients with schizophrenia in reducing caregiver burden and improving health status. A quasi-experimental research design was adopted. The research location was in a psychiatric hospital in Northern Taiwan.
Psychiatric Services, Ahead of Print.
The excitatory, ligand-gated α7 nicotinic acetylcholine receptor (nAChR) has been implicated in the pathophysiology of schizophrenia based on convergent genetic, post-mortem, and psychopharmacological studies (reviewed in Freedman, 2014). Preclinical animal studies (reviewed in Lewis et al., 2017), as well as early phase clini cal studies of patients with schizophrenia (Olincy et al., 2006), suggest α7 nAChR agonists may be useful for treatment of cognitive dysfunction in schizophrenia. However, results of larger randomized placebo-controlled clinical trials of α7 nAChR agonists with a primary cognitive o...