Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction.

Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction.
Curr Opin Microbiol. 2017 Aug 04;39:1-6
Authors: Litvak Y, Byndloss MX, Tsolis RM, Bäumler AJ
Abstract
A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while dysbiosis is often associated with a sustained increase in the abundance of facultative anaerobic Proteobacteria, indicative of a disruption in anaerobiosis. The colonic epithelium is hypoxic, but intestinal inflammation or antibiotic treatment increases epithelial oxygenation in the colon, thereby disrupting anaerobiosis to drive a dysbiotic expansion of facultative anaerobic Proteobacteria through aerobic respiration. These observations suggest a dysbiotic expansion of Proteobacteria is a potential diagnostic microbial signature of epithelial dysfunction, a hypothesis that could spawn novel preventative or therapeutic strategies for a broad spectrum of human diseases.
PMID: 28783509 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - August 4, 2017 Category: Microbiology Authors: Litvak Y, Byndloss MX, Tsolis RM, Bäumler AJ Tags: Curr Opin Microbiol Source Type: research