Science News » Patient-Derived Support Cells Stunt Mouse Brain Development

Support cells generated from patients with childhood onset schizophrenia stunted neural circuit development when grafted into developing mouse brains.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news

Related Links:

In this study, epigenome-wide patterns of methylation were measured in schizophrenia suicide attempters (n = 54) and in schizophrenia non suicide attempters (n = 69) using DNA extracted from white blood cells. Analyses focused on identifying differentially methylated CpG sites and gene regions between attempters and non-attempters. We identified the CpG site cg19647197 within the CCDC53 gene, which is characterized by hypomethylation of WBC in schizophrenia attempters compared to non-attempters. Our results suggest that there is variation in DNA methylation associated with suicide attempt that may offer novel highl...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Abstract The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It is estimated that the human gut is colonized by up to 1018 microorganisms, mostly anaerobic bacteria. The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier, digestion and absorption. The correlation between gut dysbiosis and development of psychiatric, autoimmune and allergic diseases as well as bidirectional communication between brain and gut microflora have been shown. Recent findings suggest that specific bacteria can be involved in the dev...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
CONCLUSIONS: Together, results demonstrate the effectiveness of new remediation protocols that target mid-level visual processing, which generalized to select visual cognitive functions. PMID: 30019984 [PubMed - as supplied by publisher]
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
This study aimed to meet this need by examining potential risk fac...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Publication date: Available online 19 July 2018Source: Journal of Contextual Behavioral ScienceAuthor(s): Maria João Martins, Célia Barreto Carvalho, António Macedo, Ana Telma Pereira, Christine Braehler, Andrew Gumley, Paula CastilhoAbstractDescribed as a contextual behavioural approach, Compassion-focused Therapy (CFT) aims at helping people develop compassionate relationships both with others and with the self. CFT has been used to promote recovery in psychosis with promising results. The development process of the Compassionate Approach to Schizophrenia and Schizoaffective Disorder (COMPASS) builds...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
Scientists are learning that certain foods — either because of their natural ingredients or because of added chemicals — can have significant effects on health. One way in which food can exert this influence health is through inflammation, which is triggered by the immune system and may have an impact on the risk of developing a number of chronic conditions. Plenty of foods contribute to inflammation, from sugar to saturated fat. But in a new study, cured meats are under scrutiny. They usually contain nitrates, a group of chemicals used as a preservative to cure meats like jerky, meat sticks and hot dogs, and...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime Source Type: news
----Searching for the fundamental mental processes that cut across diagnostic categories, driving confusion and distress //BPS Research DigestA new paper in Journal of Clinical Psychology is the just the latest to take a trans-diagnostic approach to mental healthBy Alex FraderaThe number of psychiatric diagnoses keep on growing, with perhaps ten times as many categories now as there were 50 years ago. This may in part reflect our growing knowledge, which is welcome. But the sheer density of diagnoses makes it difficult for researchers or clinicians to see the wood for the trees, and it encourages them to settle into s...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - Category: Neuroscience Source Type: blogs
CONCLUSIONS: The iterative co-creation process based upon a high degree of patient involvement resulted in a set of PROMs, a national measurement concept, and patient recommendations for implementation. The cooperation between patients and professionals was successful. PMID: 30015541 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Authors: Khalil AH, ELNahas G, Ramy H, Abdel Aziz K, Elkholy H, El-Ghamry R Abstract OBJECTIVE: To study the effect of a culturally adapted, structured family intervention on symptom severity, medication attitudes and knowledge, social functioning and quality of life in patients with schizophrenia. METHODS: Thirty subjects with schizophrenia were selected to receive 14 sessions of a culturally adapted behavioural family psychoeducational programme (BFPEP). Another 30 subjects received standard treatment as usual (STU) for 6 months. Pre- and post-intervention outcomes were assessed using the Positive and Negativ...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
Contributors : Lei Gu ; Dean Bok ; Fei Yu ; Joseph Caprioli ; Natik PiriSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRbfox1 is a splicing regulator that has been associated with various neurological conditions such as autism spectrum disorder, mental retardation, epilepsy, attention-deficit/hyperactivity disorder, and schizophrenia. We show that in adult rodent retinas, Rbfox1 is expressed in all types of retinal ganglion cells (RGCs) as well as in certain subsets of amacrine cells (ACs) within the inner nuclear and ganglion cell layers. In developing retinas, Rbfox1 can be detecte...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
More News: Brain | Child Development | Men | Neurology | Psychiatry | Schizophrenia | Science