Science News » Patient-Derived Support Cells Stunt Mouse Brain Development
Support cells generated from patients with childhood onset schizophrenia stunted neural circuit development when grafted into developing mouse brains.
Michael Green, neuroscientist and professor of psychiatry and biobehavioral sciences at UCLA, has been fascinated with the human brain, behavior and mental illness since his undergraduate days.In graduate school at Cornell University, he worked in a state hospital with people who had schizophrenia. While working with them, Green noticed he could be having an ordinary conversation one moment, and then suddenly the conversation would shift dramatically, erasing the common ground they had established.“I have never encountered a condition so perplexing, both scientifically and clinically,” said Green, who is a seni...
ConclusionBreast cancer patients with mental illness should be closely managed by a cross-functional care team, including a psychiatrist, a primary care physician, and an oncologist, to ensure adequate care is received within an appropriate timeframe.
CONCLUSIONS: Individuals with schizophrenia received lower-quality diabetes care compared with those without schizophrenia. However, absolute differences in care were modest. PMID: 29032706 [PubMed - as supplied by publisher]
Authors: Kowalchuk C, Teo C, Wilson V, Chintoh A, Lam L, Agarwal SM, Giacca A, Remington GJ, Hahn MK Abstract BACKGROUND: Insulin receptors are widely expressed in the brain and may represent a crossroad between metabolic and cognitive disorders. Although antipsychotics, such as olanzapine, are the cornerstone treatment for schizophrenia, they are associated with high rates of type 2 diabetes and lack efficacy for illness-related cognitive deficits. Historically, this risk of diabetes was attributed to the weight gain propensity of antipsychotics, but recent work suggests antipsychotics can have weight-independent ...
CONCLUSIONS: SZ patients with high levels of negative symptoms are not merely effort averse, but have more difficulty effectively allocating effort and anticipating pleasure engaging in effortful activities. It may be the case that continuously failing to achieve reinforcement from engagement and participation may lead SZ patients to form certain negative beliefs about their abilities which contributes to amotivation and cognitive deficits. Lastly, our findings provide further support for a link between SZ patients functional daily living skills their effort allocation. PMID: 29031122 [PubMed - as supplied by publisher]
Authors: Buckley PF PMID: 29035102 [PubMed - in process]
The largest ever big data study of schizophrenia finds that the entire communication system in the brain's white matter is disrupted in the disease.
(University of Southern California) Some 40 years since CT scans first revealed abnormalities in the brains of schizophrenia patients, international scientists say the disorder is a systemic disruption to the brain's entire communication system. The study sets the stage for future research on the debilitating mental illness that affects more than 21 million people worldwide. It is the largest analysis of 'white matter' differences in a psychiatric disorder to date.
Severe and persistent mental illnesses, such as schizophrenia and bipolar disorder, are associated with increased risk of obesity compared to the general population. While the association of lurasidone and low...
Molecular Psychiatry, Published online: 17 October 2017; doi:10.1038/mp.2017.170