Impaired theta and alpha oscillations underlying stopsignal response inhibition deficits in schizophrenia

Poor inhibitory control is a factor in schizophrenia patients (SZ) who are slow to stop initiated behaviours (response inhibition) in the stopsignal-task (slow stop-signal RT, SSRT) (Hughes et al., 2012). Faster SSRT is linked to greater activation of right inferior-frontal gyrus (rIFG) (Aron, 2011; Hughes et al., 2013) including theta-alpha oscillations (4 –12Hz) (Jha et al., 2015); unsurprisingly, Stop-related rIFG activity is diminished in SZ (Hughes et al., 2012). Here we analyse electroencephalography (EEG) oscillations from archival data (Hughes et al., 2012) time-locked to stop-signals and SSRT; in the latter case to reveal reactive stop-proce sses engaged during SSRT that may be smoothed over in the former due to inherent individual SSRT variation.

Source: Schizophrenia Research - August 7, 2017 Category: Psychiatry Authors: Patrick S. Cooper, Matthew E. Hughes Tags: Letter to the editor Source Type: research